Z
Zhaoxia Ji
Researcher at University of California, Los Angeles
Publications - 80
Citations - 14214
Zhaoxia Ji is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Nanoparticle & Surface coating. The author has an hindex of 52, co-authored 80 publications receiving 12255 citations. Previous affiliations of Zhaoxia Ji include California NanoSystems Institute & Dalian University of Technology.
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Journal ArticleDOI
Stability and Aggregation of Metal Oxide Nanoparticles in Natural Aqueous Matrices
Arturo A. Keller,Hongtao Wang,Dongxu Zhou,Hunter S. Lenihan,Gary N. Cherr,Bradley J. Cardinale,Robert J. Miller,Zhaoxia Ji +7 more
TL;DR: The electrophoretic mobility of the particles in a given aqueous media was dominated by the presence of natural organic matter (NOM) and ionic strength, and independent of pH.
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Engineered Design of Mesoporous Silica Nanoparticles to Deliver Doxorubicin and P-Glycoprotein siRNA to Overcome Drug Resistance in a Cancer Cell Line
TL;DR: It is demonstrated that mesoporous silica nanoparticles (MSNP) can be functionalized to effectively deliver a chemotherapeutic agent doxorubicin (Dox) as well as Pgp siRNA to a drug-resistant cancer cell line (KB-V1 cells) to accomplish cell killing in an additive or synergistic fashion.
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Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation
Haiyuan Zhang,Zhaoxia Ji,Tian Xia,Huan Meng,Cecile Low-Kam,Rong Liu,Suman Pokhrel,Sijie Lin,Xiang Wang,Yu-Pei Liao,Meiying Wang,Linjiang Li,Robert Rallo,Robert Damoiseaux,Donatello Telesca,Lutz Mädler,Yoram Cohen,Jeffrey I. Zink,Andre E. Nel +18 more
TL;DR: It is demonstrated that it is possible to predict the toxicity of a large series of MOx nanoparticles in the lung premised on semiconductor properties and an integrated in vitro/in vivo hazard ranking model premisedon oxidative stress.
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Codelivery of an Optimal Drug/siRNA Combination Using Mesoporous Silica Nanoparticles To Overcome Drug Resistance in Breast Cancer in Vitro and in Vivo
Huan Meng,Wilson X. Mai,Haiyuan Zhang,Min Xue,Tian Xia,Sijie Lin,Xiang Wang,Yang Zhao,Zhaoxia Ji,Jeffrey I. Zink,Andre E. Nel +10 more
TL;DR: Proof-of-principle testing of the use of a dual drug/siRNA nanocarrier to overcome Dox resistance in a xenograft is provided and the first detailed analysis of the impact of heterogeneity in the tumor microenvironment on the efficacy of siRNA delivery in vivo is provided.
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Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening.
TL;DR: The major injury paradigms that have emerged based on specific ENM properties are discussed, as well as describing the safer design of ZnO nanoparticles based on characterization of dissolution chemistry as a major predictor of toxicity.