Ming Wei

TL;DR: It was found that the T cell receptor (TCR)-CD3 complex and the Lck kinase were required for Ca2+ mobilization but not for apoptosis induction in Jurkat cells, indicating that gal-9 acts on T cells by two distinct pathways, one mimicking antigen-specific activation of the TCR with a mandatory contribution of proximal elements of theTCR complex, especially Lck, and another resulting in apoptosis that is independent of this complex.

TL;DR: One of the new monoclonal antibodies produced, 1G3, demonstrated very good sensitivity and specificity when used for immunohistochemistry and could confirm the intense and constant expression of galectin-9 by Epstein-Barr virus positive malignant cells from nasopharyngeal carcinomas.

TL;DR: A protective effect of Gal-Nab1 and Gal-nab2 on the apoptotic cell death induced by gal-9 in primary T cells is reported, and cross-species recognition will be an advantage for their assessment in pre-clinical tumor models.

TL;DR: Lentiviral transduction of the chimeric tCD2-luc2 fusion gene allows selection of cell clones with stable luciferase expression in less than seven days without antibiotic selection and will be helpful to increase the number of tumor cell lines available for in vivo imaging and assessment of novel therapeutic modalities.