Sylviane Hoos

TL;DR: New light is shed in the mechanisms regulating programmed necrosis, a key nuclear partner of AIF is elucidated, an AIF apoptogenic motif is uncovered, and chromatinolysis is uncovered in H2AX or CypA‐deficient nuclei.

TL;DR: It is demonstrated that mFcgammaRIV promotes IgE-induced lung inflammation and suggested that a similar cooperation may occur between mast cells and hFceRI-expressing lung cells in human allergic asthma.

TL;DR: The crystal structure of AMA1 from Plasmodium falciparum in complex with a peptide derived from the extracellular region of PfRON2 is determined, highlighting clear specificities of the P. falcIParum RON2-AMA1 interaction and suggesting novel approaches to antimalarial therapeutics.

TL;DR: It is proposed that attenuation of rabies virus requires expansion of the set of host PDZ proteins with which G interacts, which interferes with the finely tuned homeostasis required for survival of the infected neuron.

TL;DR: To explore the variability in biosensor studies, 150 participants from 20 countries were given the same protein samples and asked to determine kinetic rate constants, demonstrating that when this biosensor assay was designed and executed appropriately, the reported rate constants were consistent, and independent of which protein was immobilized and which biosensor was used.