Minghua Cui

TL;DR: This review summarizes the historical background, source, structure and analogues of capsicin, and capsaicin-triggered TRPV1 signaling and desensitization processes and will focus on the therapeutic roles of Capsaicin and its analogues in both normal and pathophysiological conditions.

TL;DR: A comprehensive view on the ligand– and structure-based cheminformatics approaches which are best illustrated via GPCR case studies is provided, and an appropriate combination of ligand-based knowledge with structure- based ones, i.e., integrated approach, which is emerging as a promising strategy for chemin Formatics-based G PCR drug design is discussed.

TL;DR: This review article covers the patents that claim TRPV1 antagonists and were published during 2011 – 2014 and describes the representative chemical entities with important in vitro and in vivo data.

TL;DR: It is proposed that lysosomal TM4SF5 senses and enables arginine efflux for mTORC1/S6K1 activation, and arginin-auxotroph in hepatocellular carcinoma may be targeted by blocking theArginine sensing using anti-TM4 SF5 reagents.

TL;DR: A library of glutamyl cyclase (QC) inhibitors based on the proposed binding mode of the preferred substrate, Aβ3E-42 are designed, resulting in strong interactions with the carboxylate group of Glu327 in the QC binding site and offering useful insights in designing novel QC inhibitors as a potential treatment option for AD.