Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling
Jae Woo Jung,Stephani Joy Y. Macalino,Minghua Cui,Ji Eon Kim,Hye-Jin Kim,Dae-Geun Song,Dae-Geun Song,Seo Hee Nam,Semi Kim,Sun Choi,Jung Weon Lee +10 more
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TLDR
It is proposed that lysosomal TM4SF5 senses and enables arginine efflux for mTORC1/S6K1 activation, and arginin-auxotroph in hepatocellular carcinoma may be targeted by blocking theArginine sensing using anti-TM4 SF5 reagents.About:
This article is published in Cell Metabolism.The article was published on 2019-06-04 and is currently open access. It has received 44 citations till now. The article focuses on the topics: Arginine & Amino acid transporter.read more
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mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient
Gregory A. Wyant,Monther Abu-Remaileh,Rachel L. Wolfson,Walter W. Chen,Elizaveta Freinkman,Laura V. Danai,Matthew G. Vander Heiden,Matthew G. Vander Heiden,David M. Sabatini +8 more
TL;DR: In this article, the authors validate that SLC38A9 is an arginine sensor for the mTORC1 pathway, and uncover an unexpectedly central role for SLC 38A9 in amino acid homeostasis.
Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
Robert A. Saxton,Lynne Chantranupong,Kevin E. Knockenhauer,Thomas U. Schwartz,David M. Sabatini +4 more
TL;DR: In this article, the structure and accompanying biochemistry reveal how arginine is specifically sensed by CASTOR1 and disrupts the interaction of CASTor1 with GATOR2, triggering activation of mTORC1.
Journal ArticleDOI
mTORC1 as a Regulator of Mitochondrial Functions and a Therapeutic Target in Cancer.
Karen Griselda de la Cruz López,Mariel Esperanza Toledo Guzmán,Elizabeth Ortiz Sánchez,Alejandro García Carrancá +3 more
TL;DR: The therapeutic efficacy of mTORC1 inhibitors in cancer treatments is reviewed, considering its use in combination with other drugs, with particular focus on cellular metabolism inhibitors, that could help improve their anti neoplastic effect and eliminate cancer cells in patients.
Journal ArticleDOI
Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation
Sung-Hoon Kim,Jung-Hyun Choi,Peng Wang,Christopher D. Go,Christopher D. Go,Geoffrey G. Hesketh,Anne-Claude Gingras,Anne-Claude Gingras,Seyed Mehdi Jafarnejad,Nahum Sonenberg +9 more
TL;DR: The requirement of TARS2, but not cytoplasmic threonyl-tRNA synthetase TARS, for this effect demonstrates an additional layer of complexity in the regulation of mTORC1 activity.
Journal ArticleDOI
Sensors for the mTORC1 pathway regulated by amino acids.
Xiu-zhi Li,Xianghua Yan +1 more
TL;DR: Recently, several sensors of leucine, arginine, and S-adenosylmethionine for the amino acid-stimulated mTORC1 pathway have been coming to light and characterization of these sensors is requisite for understanding how cells adjust amino acid sensing pathways to their different needs.
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