Ji Eon Kim

TL;DR: It is proposed that lysosomal TM4SF5 senses and enables arginine efflux for mTORC1/S6K1 activation, and arginin-auxotroph in hepatocellular carcinoma may be targeted by blocking theArginine sensing using anti-TM4 SF5 reagents.

TL;DR: It is demonstrated that the KRS-dependent metastatic behavior of colon cancer spheroids within 3D gels requires communication between cellular molecules and extracellular soluble factors and neighboring cells, and KRS in colon cancer cells remodels the microenvironment to promote metastasis.

TL;DR: Findings suggest that, during fibrosis development, EPRS plays roles in nontranslational processes of ECM expression via intracellular signaling regulation upon TGF‐β1 stimulation.

TL;DR: It was showed that TM4SF5 dynamically interacted with EGFR and integrin α5 in migratory cells to control directionality and invasion, and importantly, these TM4 SF5 functions were dependent on cholesterol, TM3SF5 post‐translational modifications, and EGFRand integrinα5 activity.

TL;DR: In this article, the authors investigated the contribution of TM4SF5 to liver pathology using transgenic and KO mice, diet- or drug-treated mice, in vitro primary cells, and in human tissue.