Seo Hee Nam

TL;DR: It is found that TM4 SF5‐dependent sphere growth correlated with CD24−, aldehyde dehydrogenase (ALDH) activity, as well as a physical association between CD44 and TM4SF5, which promotes self‐renewal and CTC properties supported by TM 4SF5+/CD44+(TM4SF 5‐bound)/ALDH+/ CD24–/CD24− markers during HCC metastasis.

TL;DR: It is proposed that lysosomal TM4SF5 senses and enables arginine efflux for mTORC1/S6K1 activation, and arginin-auxotroph in hepatocellular carcinoma may be targeted by blocking theArginine sensing using anti-TM4 SF5 reagents.

TL;DR: It is demonstrated that the KRS-dependent metastatic behavior of colon cancer spheroids within 3D gels requires communication between cellular molecules and extracellular soluble factors and neighboring cells, and KRS in colon cancer cells remodels the microenvironment to promote metastasis.

TL;DR: Taken together, TM4SF5 appears to play a role in liver malignancy by controlling the levels of tetraspanins on the cell surface, and could provide a promising therapeutic target for the treatment of livermalignancies.

TL;DR: Findings suggest that, during fibrosis development, EPRS plays roles in nontranslational processes of ECM expression via intracellular signaling regulation upon TGF‐β1 stimulation.