M
Minghua Cui
Researcher at Ewha Womans University
Publications - 28
Citations - 674
Minghua Cui is an academic researcher from Ewha Womans University. The author has contributed to research in topics: TRPV1 & Docking (molecular). The author has an hindex of 13, co-authored 27 publications receiving 495 citations. Previous affiliations of Minghua Cui include Wonkwang University.
Papers
More filters
Journal ArticleDOI
Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases
TL;DR: This review summarizes the historical background, source, structure and analogues of capsicin, and capsaicin-triggered TRPV1 signaling and desensitization processes and will focus on the therapeutic roles of Capsaicin and its analogues in both normal and pathophysiological conditions.
Journal ArticleDOI
Exploring G protein-coupled receptors (GPCRs) ligand space via cheminformatics approaches: Impact on rational drug design
Shaherin Basith,Minghua Cui,Stephani Joy Y. Macalino,Jongmi Park,Nina Abigail B. Clavio,Soosung Kang,Sun Choi +6 more
TL;DR: A comprehensive view on the ligand– and structure-based cheminformatics approaches which are best illustrated via GPCR case studies is provided, and an appropriate combination of ligand-based knowledge with structure- based ones, i.e., integrated approach, which is emerging as a promising strategy for chemin Formatics-based G PCR drug design is discussed.
Journal ArticleDOI
Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 – 2014)
TL;DR: This review article covers the patents that claim TRPV1 antagonists and were published during 2011 – 2014 and describes the representative chemical entities with important in vitro and in vivo data.
Journal ArticleDOI
Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling
Jae Woo Jung,Stephani Joy Y. Macalino,Minghua Cui,Ji Eon Kim,Hye-Jin Kim,Dae-Geun Song,Dae-Geun Song,Seo Hee Nam,Semi Kim,Sun Choi,Jung Weon Lee +10 more
TL;DR: It is proposed that lysosomal TM4SF5 senses and enables arginine efflux for mTORC1/S6K1 activation, and arginin-auxotroph in hepatocellular carcinoma may be targeted by blocking theArginine sensing using anti-TM4 SF5 reagents.
Journal ArticleDOI
Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design.
Van-Hai Hoang,Phuong-Thao Tran,Phuong-Thao Tran,Minghua Cui,Van Hoa Ngo,Jihyae Ann,Jongmi Park,Jiyoun Lee,Kwang-Hyun Choi,Hanyang Cho,Hee Kim,Ha Hee Jin,Hyun Seok Hong,Sun Choi,Young Ho Kim,Jeewoo Lee +15 more
TL;DR: A library of glutamyl cyclase (QC) inhibitors based on the proposed binding mode of the preferred substrate, Aβ3E-42 are designed, resulting in strong interactions with the carboxylate group of Glu327 in the QC binding site and offering useful insights in designing novel QC inhibitors as a potential treatment option for AD.