다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

Polydopamine and Its Derivative Materials: Synthesis and Promising Applications in Energy, Environmental, and Biomedical Fields

Since its discovery, the asymmetric Fano resonance has been a characteristic feature of interacting quantum systems. The shape of this resonance is distinctively different from that of conventional symmetric resonance curves. Recently, the Fano resonance has been found in plasmonic nanoparticles, photonic crystals, and electromagnetic metamaterials. The steep dispersion of the Fano resonance profile promises applications in sensors, lasing, switching, and nonlinear and slow-light devices.

The Fano resonance in plasmonic nanostructures and metamaterials

Nanoimprinting lithography (NIL) is a manufacturing process that can produce macroscale surface areas with nanoscale features. In this paper, this technique is used to solve three fundamental issues for the application of localized surface plasmonic resonance (LSPR) in practical clinical measurements: assay sensitivity, chip-to-chip variance, and the ability to perform assays in human serum. Using NIL, arrays of 140 nm square features were fabricated on a sensing area of 1.5 mm x 1.5 mm with low cost. The high reproducibility of NIL allowed for the use of a one-chip, one-measurement approach with 12 individually manufactured surfaces with minimal chip-to-chip variations. To better approximate a real world setting, all chips were modified with a biocompatible, multi-component monolayer and inter-chip variability was assessed by measuring a bioanalyte standard (2.5−75 ng/ml) in the presence of a complex biofluid, human serum. In this setting, nanoimprinted LSPR chips were able to provide sufficient characteristics for a ‘low-tech’ approach to laboratory-based bioanalyte measurement, including: 1) sufficient size to interface with a common laboratory light source and detector without the need for a microscope, 2) high sensitivity in serum with a cardiac troponin limit of detection of 0.55 ng/ml, and 3) very low variability in chip manufacturing to produce a figure of merit (FOM) of 10.5. These findings drive LSPR closer to technical comparability with ELISA-based assays while preserving the unique particularities of a LSPR based sensor, suitability for multiplexing and miniaturization, and point-of-care detections.

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Quantification of a cardiac biomarker in human serum using extraordinary optical transmission (EOT).

Total Reflection Metasurface with Pure Modulated Signal

Many acoustic metamaterials suffer from a narrow bandwidth transmission because of the impedance mismatch at the air-metamaterial interface. In this paper, a two-dimensional impedance-matched metamaterial with broadband transmission performance is investigated. The impedance matching layer is introduced for a gradient variation of effective impedance from the inlet of the unit to the outlet. The effective medium theory and corresponding effective model are used to explain the underlying mechanism. The improved energy transmission of our designs is demonstrated by experiment and numerical simulation within a broad frequency bandwidth over 6 kHz. Our impedance-matched design can be used to enhance sound absorption, which is expected to present improved acoustic performance in the applications of acoustic damper and muffler.

Wide bandwidth acoustic transmission via coiled-up metamaterial with impedance matching layers

In this work, we propose a method that can realize switchable spatial arrangement of the donut-shaped focusing beams through an engineered microsphere, tuned by changing the polarization state of an incident light. In this polarization-dependent light manipulation, the engineered microsphere is designed and fabricated by focused ion beam (FIB). We simulate and experimentally characterize the focus performance of the engineered microsphere. Under the light incidence with radial polarization, multiple focused donut beams are formed along optical axis. By adding an additional linear polarizer with a rotatable relative angle, the pair of donut beams can be re-arranged in the same transverse plane and stay close to each other. Experimental results and numerical simulation are in good agreement. Such tunable polarization-dependent micro-optics can be used for multiplane imaging applications.

Minghui Hong

Papers

Quantification of a cardiac biomarker in human serum using extraordinary optical transmission (EOT).

Total Reflection Metasurface with Pure Modulated Signal

Wide bandwidth acoustic transmission via coiled-up metamaterial with impedance matching layers

Formation of polarization-dependent optical vortex beams via an engineered microsphere.

Time-resolved plasma emission spectrum analyses at the early stage of laser ablation