다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

Polydopamine and Its Derivative Materials: Synthesis and Promising Applications in Energy, Environmental, and Biomedical Fields

Since its discovery, the asymmetric Fano resonance has been a characteristic feature of interacting quantum systems. The shape of this resonance is distinctively different from that of conventional symmetric resonance curves. Recently, the Fano resonance has been found in plasmonic nanoparticles, photonic crystals, and electromagnetic metamaterials. The steep dispersion of the Fano resonance profile promises applications in sensors, lasing, switching, and nonlinear and slow-light devices.

The Fano resonance in plasmonic nanostructures and metamaterials

Development of a prototype of a portable optical sensing system is presented for fast detecting of samples’ fluorescence spectra. A compact configuration is achieved by integrating a small spectrometer, a microcontroller, a Universal Serial Bus (USB) Host Shield, a network module, and a web server. The fluorescence spectra of a tested sample can be obtained. Then the test data are sent through network communication to our Cloud Server which can store the data for further analyses. With this configuration, test results can be revealed in a short time and downloaded by users to their laptops, tablets or cellphones anytime and anywhere.

A portable optical sensing system for rapid detection of fluorescence spectra

Polarization-independent optical properties of rotor-shaped nanostructures provide an opportunity to develop actual plasmonic systems. For instance, use of such structures in hybrid oligomers improves oligomers potential applications significantly.

Planar isotropic rotor-shaped nanostructures: An alternative to develop oligomers

The local field enhancement in proximity of metallic nanostructures can strongly modify the excitation and emission behaviors for the nearby fluorophore. In this paper, Maxwell's time-dependent curl equations are solved by the finite-difference time-domain method to investigate the electric field enhancement around an atomic-force microscopy (AFM) tip and a Au nanosphere (NS). To lower the background fluorescence signal, we proposed to induce the fluorescence quenching by placing the emitter at an optimized position that is 2 nm away from the Au NS. The AFM tip is thereby moved to the vicinity of the emitter quenched by the Au NS. The fluorescence enhancement factor (FEF) increases rapidly when the tip approaches the Au NS. A maximum FEF of 1500-fold is obtained when their separation is 4 nm. By laterally scanning the tip over the Au NS at a constant height, the full width at half-maximum of fluorescence's signal peak with respect to tip position is around 20 nm. This high sensitivity of the FEF on the relative position of the tip and Au NS provides valuable information to guide future experiments on high-resolution optical imaging and fluorescence enhancement for high quantum yield emitters.

Simulation of fluorescence enhancement by an AFM tip on a gold particle quenched emitter.

For a biosensing platform to have clinical relevance in point-of-care (POC) settings, assay sensitivity, reproducibility, and ability to reliably monitor analytes against the background of human serum are crucial.
Nanoimprinting lithography (NIL) was used to fabricate, at a low cost, sensing areas as large as 1.5 mm x 1.5 mm. The sensing surface was made of high-fidelity arrays of nanoholes, each with an area of about 140 nm2. The great reproducibility of NIL made it possible to employ a one-chip, one-measurement strategy on 12 individually manufactured surfaces, with minimal chip-to-chip variation. These nanoimprinted localized surface plasmon resonance (LSPR) chips were extensively tested on their ability to reliably measure a bioanalyte at concentrations varying from 2.5 to 75 ng/mL amidst the background of a complex biofluid-in this case, human serum. The high fidelity of NIL enables the generation of large sensing areas, which in turn eliminates the need for a microscope, as this biosensor can be easily interfaced with a commonly available laboratory light source. These biosensors can detect cardiac troponin in serum with a high sensitivity, at a limit of detection (LOD) of 0.55 ng/mL, which is clinically relevant. They also show low chip-to-chip variance (due to the high quality of the fabrication process). The results are commensurable with widely used enzyme-linked immunosorbent assay (ELISA)-based assays, but the technique retains the advantages of an LSPR-based sensing platform (i.e., amenability to miniaturization and multiplexing, making it more feasible for POC applications).

/pdf/using-extraordinary-optical-transmission-to-quantify-cardiac-16qy8oy9s5.pdf

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum.

Laser cleaning was demonstrated both theoretically and experimentally to be an effective cleaning technique forremoving particulate and fihn-type contaminants from solid surfaces in this paper. The 1aserinduced removal offilm-type contaminants from IC (IntegTated Circuit) packages, IC mould, Printed Circuit Board and flexible circuitwas StUdied. The cleaning models were established for removal of particles from substrate surfaces without andwith a thin liquid layer by taking adhesion forces and cleaning force into account. The models not only explain theinfluence of laser fluence on cleaning efficiency, but also predict the cleaning thresholds. Laser-induced removalof particles from magnetic sliders and disk surfaces was investigated. Monitoring of laser cleaning by acousticwave, electric field signal and particle counter was also addressed.KEYWORDS: Laser cleaning, cleaning model, cleaning mechanisms, cleaning applications.

Minghui Hong

Papers

A portable optical sensing system for rapid detection of fluorescence spectra

Planar isotropic rotor-shaped nanostructures: An alternative to develop oligomers

Simulation of fluorescence enhancement by an AFM tip on a gold particle quenched emitter.

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum.

Science and engineering in laser surface cleaning