M
Mireya Gonzalez-Begne
Researcher at University of Rochester Medical Center
Publications - 16
Citations - 1954
Mireya Gonzalez-Begne is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Saliva & Salivary gland. The author has an hindex of 15, co-authored 16 publications receiving 1721 citations. Previous affiliations of Mireya Gonzalez-Begne include University of Connecticut Health Center & University of Southern California.
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Journal ArticleDOI
Symbiotic Relationship between Streptococcus mutans and Candida albicans Synergizes Virulence of Plaque Biofilms In Vivo
Megan L. Falsetta,Marlise I. Klein,Punsiri M. Colonne,Kathleen Scott-Anne,Stacy Gregoire,Chia-Hua Pai,Mireya Gonzalez-Begne,Gene E. Watson,Damian J. Krysan,William H. Bowen,Hyun Koo,Hyun Koo +11 more
TL;DR: It is shown that the ability of these organisms together to form biofilms is enhanced in vitro and in vivo, and a novel mutualistic bacterium-fungus relationship that occurs at a clinically relevant site to amplify the severity of a ubiquitous infectious disease is demonstrated.
Journal ArticleDOI
The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions
Paul C. Denny,Fred K. Hagen,Markus Hardt,Lujian Liao,Weihong Yan,Martha Arellanno,Sara Bassilian,Gurrinder S. Bedi,Pinmannee Boontheung,Daniel Cociorva,Claire M. Delahunty,Trish Denny,Jason Dunsmore,Kym F. Faull,Joyce Gilligan,Mireya Gonzalez-Begne,Frédéric Halgand,Steven C. Hall,Xuemei Han,Bradley S. Henson,Johannes Hewel,Shen Hu,Sherry Jeffrey,Jiang Jiang,Joseph A. Loo,Rachel R. Ogorzalek Loo,Daniel Malamud,James E. Melvin,Olga Miroshnychenko,Mahvash Navazesh,Richard K. Niles,Sung Kyu Park,Akraporn Prakobphol,Prasanna Ramachandran,Megan Richert,Sarah Robinson,Melissa Sondej,Puneet Souda,Mark A. Sullivan,Jona Takashima,Shawn Than,Jianghua Wang,Julian P. Whitelegge,H. Ewa Witkowska,Lawrence E. Wolinsky,Yongming Xie,Tao Xu,Weixia Yu,Jimmy Ytterberg,David T.W. Wong,John R. Yates,Susan J. Fisher +51 more
TL;DR: A catalogue of the salivary proteome of healthy individuals allows future analyses ofSaliva samples from individuals with oral and systemic diseases, with the goal of identifying biomarkers with diagnostic and/or prognostic value for these conditions; another possibility is the discovery of therapeutic targets.
Journal ArticleDOI
Proteomic Analysis of Human Parotid Gland Exosomes by Multidimensional Protein Identification Technology (MudPIT)
Mireya Gonzalez-Begne,Bingwen Lu,Xuemei Han,Fred K. Hagen,Arthur R. Hand,James E. Melvin,John R. Yates +6 more
TL;DR: The present study used a mass spectrometry-based, shotgun proteomics approach to explore the possibility that a subset of the proteins found in saliva are derived from exosomes, membrane-bound vesicles of endosomal origin within multivesicular endosomes.
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Systematic comparison of the human saliva and plasma proteomes
Weihong Yan,Rolf Apweiler,Brian M. Balgley,Pinmanee Boontheung,Jonathan L. Bundy,Benjamin Cargile,Steve W. Cole,Xueping Fang,Mireya Gonzalez-Begne,Timothy J. Griffin,Fred K. Hagen,Shen Hu,Lawrence E. Wolinsky,Cheng S. Lee,Daniel Malamud,James E. Melvin,Rajasree Menon,Michael Mueller,Renli Qiao,Nelson L. Rhodus,Joel Sevinsky,David J. States,James Stephenson,Shawn Than,John R. Yates,Weixia Yu,Hongwei Xie,Yongming Xie,Gilbert S. Omenn,Joseph A. Loo,David T.W. Wong +30 more
TL;DR: A comprehensive catalog of the salivary proteome and its comparison to the plasma proteome provides insights useful for future study, such as exploration of potential biomarkers for disease diagnostics.
Journal ArticleDOI
Tmem16A Encodes the Ca2+-activated Cl− Channel in Mouse Submandibular Salivary Gland Acinar Cells
Victor G. Romanenko,Marcelo A. Catalán,David A. Brown,Ilva Putzier,H. Criss Hartzell,Alan D. Marmorstein,Mireya Gonzalez-Begne,Jason R. Rock,Brian D. Harfe,James E. Melvin +9 more
TL;DR: It is demonstrated that both Tmem16A and Best2 generate Ca2+-activated Cl− current in vitro with similar properties to those expressed in native cells, yet only T Mem16A appears to be a critical component of the acinar Ca2-activation Cl− channel complex that is essential for saliva production by the submandibular gland.