M
Misha Soskine
Researcher at University of Groningen
Publications - 23
Citations - 1513
Misha Soskine is an academic researcher from University of Groningen. The author has contributed to research in topics: Nanopore & Dimer. The author has an hindex of 17, co-authored 22 publications receiving 1249 citations. Previous affiliations of Misha Soskine include Weizmann Institute of Science & Katholieke Universiteit Leuven.
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Journal ArticleDOI
Mutational effects and the evolution of new protein functions
Misha Soskine,Dan S. Tawfik +1 more
TL;DR: This work proposes several factors that can affect the divergence of new protein functions, including mutational trade-offs and hidden, or apparently neutral, variation.
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Electro-osmotic capture and ionic discrimination of peptide and protein biomarkers with FraC nanopores
TL;DR: It is shown that an electro-osmotic flow through Fragaceatoxin C (FraC) nanopores can be engineered to allow the entry of polypeptides at a fixed potential regardless of the charge composition of thepolypeptide.
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Crosslinking of membrane-embedded cysteines reveals contact points in the EmrE oligomer
TL;DR: V vicinal cysteine-substituted residues in the EmrE oligomer were identified and should be useful for other proteins with Cysteine residues in a low-dielectric environment.
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Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores
TL;DR: A nanopore based on the bacterial toxin ClyA is developed, in conjunction with binding proteins for glucose and asparagine, to detect these biomolecules simultaneously from a variety of unprocessed, diluted body fluids.
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Single-Molecule Analyte Recognition with ClyA Nanopores Equipped with Internal Protein Adaptors
TL;DR: It is shown that single enzymes can be functionally and reversibly trapped inside the confined space of a ClyA nanopore and the binding of ligands to the internalized proteins is mirrored by specific changes to the nanopore conductance.