S
Seokmann Hong
Researcher at Sejong University
Publications - 76
Citations - 4634
Seokmann Hong is an academic researcher from Sejong University. The author has contributed to research in topics: Natural killer T cell & Immune system. The author has an hindex of 23, co-authored 70 publications receiving 4440 citations. Previous affiliations of Seokmann Hong include University of California, San Francisco & Vanderbilt University.
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Journal ArticleDOI
CD1d1 Mutant Mice Are Deficient in Natural T Cells That PromptlyProduce IL-4
Sanjeev Kumar Mendiratta,W. David Martin,Seokmann Hong,Alina Boesteanu,Sebastian Joyce,Luc Van Kaer +5 more
TL;DR: A critical role for CD1 is demonstrated in the positive selection and function of natural T cells that coexpress the T cell receptor (TCR) and the natural killer cell receptor NK1.1.
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The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice.
Seokmann Hong,Michael T. Wilson,Isao Serizawa,Lan Wu,Nagendra Singh,Olga V. Naidenko,Toru Miura,Tomoku Haba,David C. Scherer,Jie Wei,Mitchell Kronenberg,Yasuhiko Koezuka,Luc Van Kaer +12 more
TL;DR: It is shown that α-GalCer prevents development of diabetes in wild-type but not CD1d-deficient NOD mice, and this findings indicate thatα- GalCer might be useful for therapeutic intervention in human diseases characterized by Th1-mediated pathology such as Type 1 diabetes.
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Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis.
Avneesh K. Singh,Michael T. Wilson,Seokmann Hong,Danyvid Olivares-Villagómez,Caigan Du,Aleksandar K. Stanic,Sebastian Joyce,Subramaniam Sriram,Yasuhiko Koezuka,Luc Van Kaer +9 more
TL;DR: It is shown that activation of Vα14 NKT cells by the glycosphingolipid α-galactosylceramide (α-GalCer) protects susceptible mice against EAE, indicating a critical role for both the IL-4 and IL-10 cytokines and an intact CD1d antigen presentation pathway.
Journal Article
Cutting Edge: Activation of NK T Cells by CD1d and α-Galactosylceramide Directs Conventional T Cells to the Acquisition of a Th2 Phenotype
Nagendra Singh,Seokmann Hong,David C. Scherer,David C. Scherer,Isao Serizawa,Nicolas Burdin,Mitchell Kronenberg,Yasuhiko Koezuka,Luc Van Kaer +8 more
TL;DR: Findings indicate that alpha-GalCer may be useful for modulating immune responses toward a Th2 phenotype during prophylaxis and therapy.
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Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice.
Alexandra O. Sousa,Richard J. Mazzaccaro,Robert G. Russell,Francis K. Lee,Oliver C. Turner,Seokmann Hong,Luc Van Kaer,Barry R. Bloom +7 more
TL;DR: It is suggested here that both classical and nonclassical MHC class I-restricted T cells, distinct from CD1d-restricted cells, may be involved in protective immune responses against tuberculosis.