Mitsuhiro Fukata

TL;DR: A primary human AML xenotransplantation model using newborn nonobese diabetic/severe combined immunodeficient/interleukin (NOD/SCID/IL)2rγnull mice carrying a complete null mutation of the cytokine γc upon the SCID background is developed, demonstrating that LS cells exclusively recapitulate AML and retain self-renewal capacity in vivo.

TL;DR: The identification of CD34+CD38+CD19+ self-renewing B-ALL cells proposes a hierarchy of leukemia-initiating cells (LICs) distinct from that of AML, and provides a powerful tool for directly studying leukemogenesis and for developing therapeutic strategies.

TL;DR: Investigation of BM cells and BM-derived hematopoietic stem/progenitor cells from enhanced GFP (eGFP) transgenic mice found that some of these cells are BM- derived antigen-presenting cells such as dendritic cells and macrophages.

TL;DR: In this paper, green fluorescent protein (GFP)-labeled BM Lin-ScaI+ hematopoietic progenitors were transplanted into neonatal mice constitutively expressing cyan fluorescence protein (CFP).

TL;DR: The authors' results indicate that HSCs resulted in the generation of cardiomyocytes via myeloid intermediates by fusion-dependent mechanism, which could potentially allow more effective cell-based therapy for cardiac repair.