Naoyuki Uchida

TL;DR: A primary human AML xenotransplantation model using newborn nonobese diabetic/severe combined immunodeficient/interleukin (NOD/SCID/IL)2rγnull mice carrying a complete null mutation of the cytokine γc upon the SCID background is developed, demonstrating that LS cells exclusively recapitulate AML and retain self-renewal capacity in vivo.

TL;DR: The data indicate that the HSC compartment consists of a limited number of distinct HSC subsets, each with predictable behavior, which could provide a basis for the diagnosis of perturbed patterns of HSCs potentially caused by disease or aging.

TL;DR: It is shown, for the first time, that SP cells are present in the second-trimester human fetal liver and that early in ontogeny they express CD34, suggesting that the SP phenotype is an important and distinguishing property of human hematopoietic stem cells.

TL;DR: Exogenous growth factors can differentially affect the ability of HSCs to execute a self-renewal division within a single cell cycle even when the kinetics of proliferation are the same.

TL;DR: The Rhodamine-123 and Hoechst 33342 efflux properties of murine HSCs fluctuate in the same fashion as a number of other HSC markers, suggesting these are regulated by a common control mechanism that operates independently of that regulating the regenerative function of HSCS.