Noriyuki Saito

TL;DR: A primary human AML xenotransplantation model using newborn nonobese diabetic/severe combined immunodeficient/interleukin (NOD/SCID/IL)2rγnull mice carrying a complete null mutation of the cytokine γc upon the SCID background is developed, demonstrating that LS cells exclusively recapitulate AML and retain self-renewal capacity in vivo.

TL;DR: The identification of CD34+CD38+CD19+ self-renewing B-ALL cells proposes a hierarchy of leukemia-initiating cells (LICs) distinct from that of AML, and provides a powerful tool for directly studying leukemogenesis and for developing therapeutic strategies.

TL;DR: HHV-6 encephalitis should be considered if CNS dysfunction develops concomitant to high-level plasma HHV- 6 DNA after allogeneic HCT, and UCBT is a significant risk factor.

TL;DR: It is proposed that human DCs use unique and flexible developmental programs that cannot be categorized into the conventional myeloid or lymphoid pathway.

TL;DR: Patients with HHV6-associated encephalitis/myelitis should be alert to this rare but often fatal complication, particularly for those who receive 2 or more HSCTs using UCB, and physicians should be alerted to the incidence of this complication when the analysis was restricted to a second or more UCBT recipients.