B
Bonnie L. Lyons
Publications - 36
Citations - 5141
Bonnie L. Lyons is an academic researcher. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 21, co-authored 35 publications receiving 4713 citations.
Papers
More filters
Journal ArticleDOI
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.
Leonard D. Shultz,Bonnie L. Lyons,Lisa M. Burzenski,Bruce Gott,Xiaohua Chen,Stanley Chaleff,Malak Kotb,Stephen D. Gillies,Marie King,Julie A. Mangada,Dale L. Greiner,Rupert Handgretinger +11 more
TL;DR: NOD-scid IL2Rγnull mice engrafted with human mobilized blood stem cells provide a new in vivo long-lived model of robust multilineage human HSC engraftment.
Journal ArticleDOI
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.
Fumihiko Ishikawa,Shuro Yoshida,Yoriko Saito,Atsushi Hijikata,Hiroshi Kitamura,Satoshi Tanaka,Ryu Nakamura,Toru Tanaka,Hiroko Tomiyama,Noriyuki Saito,Mitsuhiro Fukata,Toshihiro Miyamoto,Bonnie L. Lyons,Koichi Ohshima,Naoyuki Uchida,Shuichi Taniguchi,Osamu Ohara,Koichi Akashi,Koichi Akashi,Mine Harada,Leonard D. Shultz +20 more
TL;DR: A primary human AML xenotransplantation model using newborn nonobese diabetic/severe combined immunodeficient/interleukin (NOD/SCID/IL)2rγnull mice carrying a complete null mutation of the cytokine γc upon the SCID background is developed, demonstrating that LS cells exclusively recapitulate AML and retain self-renewal capacity in vivo.
Journal ArticleDOI
Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chainnull mice
Fumihiko Ishikawa,Masaki Yasukawa,Bonnie L. Lyons,Shuro Yoshida,Toshihiro Miyamoto,Goichi Yoshimoto,Takeshi Watanabe,Koichi Akashi,Leonard D. Shultz,Mine Harada +9 more
TL;DR: A new nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse line harboring a complete null mutation of the common cytokine receptor γ chain efficiently supports development of functional human hemato-lymphopoiesis.
Journal ArticleDOI
Human Lymphoid and Myeloid Cell Development in NOD/LtSz-scid IL2rγnull Mice Engrafted with Mobilized Human Hematopoietic Stem Cells.
Leonard D. Shultz,Bonnie L. Lyons,Lisa M. Burzenski,Bruce Gott,Xiang Chen,Stanley Chaleff,Malak Kotb,Stephen D. Gillies,Dale L. Greiner,Rupert Handgretinger +9 more
TL;DR: A new genetic stock of IL-2r common γ (gamma) chain deficient NOD/LtSz-scid (NOD- scid IL2r γnull) mice that support high levels of human hematopoietic stem cell (HSC) engraftment and multilineage differentiation is developed and validated.
Journal ArticleDOI
Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.
Todd Pearson,Leonard D. Shultz,David Miller,Marie A. King,J Laning,William Fodor,Amy Cuthbert,Lisa M. Burzenski,Bruce Gott,Bonnie L. Lyons,Oded Foreman,Aldo A. Rossini,Dale L. Greiner +12 more
TL;DR: Data document that Rag1null and scid stocks of immunodeficient NOD mice harbouring the IL2rγnull mutation support similar levels of human lymphohaematopoietic cell engraftment.