M
Mobina Alemi
Researcher at University of Porto
Publications - 11
Citations - 288
Mobina Alemi is an academic researcher from University of Porto. The author has contributed to research in topics: Transthyretin & Internal medicine. The author has an hindex of 7, co-authored 10 publications receiving 230 citations. Previous affiliations of Mobina Alemi include Instituto de Biologia Molecular e Celular & Institute of Business & Medical Careers.
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Journal ArticleDOI
Anti-inflammatory Effect of Seeds and Callus of Nigella sativa L. Extracts on Mix Glial Cells with Regard to Their Thymoquinone Content
TL;DR: Investigation of anti-inflammatory effect of the alcoholic extracts of N. sativa seeds and its callus on mix glial cells of rat with regard to their thymoquinone (TQ) content found decrease in the TQ content of the callus was accompanied with an increase in its phenolic content and antioxidant ability.
Journal ArticleDOI
Transthyretin participates in beta-amyloid transport from the brain to the liver- involvement of the low-density lipoprotein receptor-related protein 1?
Mobina Alemi,Mobina Alemi,Cristiana Gaiteiro,Cristiana Gaiteiro,Carlos Ribeiro,Carlos Ribeiro,Luis Miguel Santos,Luis Miguel Santos,João R. Gomes,João R. Gomes,Sandra Oliveira,Sandra Oliveira,Pierre-Olivier Couraud,Babette B. Weksler,Ignacio A. Romero,Maria João Saraiva,Maria João Saraiva,Isabel Cardoso,Isabel Cardoso +18 more
TL;DR: It is shown that TTR promotes Aβ internalization and efflux in a human cerebral microvascular endothelial cell line, hCMEC/D3, and proposed that T TR acts as a carrier of Aβ at the blood-brain-barrier and liver, using LRP1.
Journal ArticleDOI
The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation.
Joana S. Cristóvão,Vanessa K. Morris,Isabel Cardoso,Isabel Cardoso,Sónia S. Leal,Javier Martínez,Hugo M. Botelho,Christoph Göbl,Rodrigo David,Katrin Kierdorf,Mobina Alemi,Mobina Alemi,Tobias Madl,Tobias Madl,Günter Fritz,Bernd Reif,Cláudio M. Gomes +16 more
TL;DR: The findings suggest that molecular targeting of S100B could be translated into development of novel approaches to ameliorate AD neurodegeneration.
Journal ArticleDOI
Transthyretin stability is critical in assisting beta amyloid clearance– Relevance of transthyretin stabilization in Alzheimer's disease
Mobina Alemi,Mobina Alemi,Sara Costa Silva,Sara Costa Silva,Sara Costa Silva,Isabel Santana,Isabel Cardoso,Isabel Cardoso +7 more
TL;DR: The absence of transthyretin in AD mice decreases brain Aβ clearance and reduces the low‐density lipoprotein receptor‐related protein 1 (LRP1) and it is possible that neuroprotection by TTR is dependent on its tetramer structural stability.
Journal ArticleDOI
Resveratrol administration increases Transthyretin protein levels ameliorating AD features- importance of transthyretin tetrameric stability.
Luis Miguel Santos,Daniela Rodrigues,Daniela Rodrigues,Mobina Alemi,Sara Costa Silva,Sara Costa Silva,Carlos Ribeiro,Isabel Cardoso +7 more
TL;DR: Resveratrol, which stabilizes the TTR tetramer results in TTR-normalized clearance, increases the protein plasma levels, which strengthens the stability hypothesis, which postulates that TTR is unstable in AD, leading to accelerated clearance and lower levels.