B
Babette B. Weksler
Researcher at Cornell University
Publications - 275
Citations - 23956
Babette B. Weksler is an academic researcher from Cornell University. The author has contributed to research in topics: Endothelial stem cell & Endothelium. The author has an hindex of 83, co-authored 274 publications receiving 22323 citations. Previous affiliations of Babette B. Weksler include Stony Brook University & United States Department of Veterans Affairs.
Papers
More filters
Journal ArticleDOI
Blood-brain barrier-specific properties of a human adult brain endothelial cell line
Babette B. Weksler,E. A. Subileau,N. Perrière,Pierre Charneau,Karen Holloway,Mathilde Leveque,H. Tricoire-Leignel,A. Nicotra,Sandrine Bourdoulous,Patric Turowski,David Male,Françoise Roux,John Greenwood,Ignacio A. Romero,P.O. Couraud +14 more
TL;DR: In this article, normal human brain endothelial cells were transduced by lentiviral vectors incorporating human telomerase or SV40 T antigen, and one was selected for expression of normal endothelial markers, including CD31, VE cadherin, and von Willebrand factor.
Journal ArticleDOI
Stimulation of Endothelial Cell Prostacyclin Production by Thrombin, Trypsin, and the Ionophore A 23187
TL;DR: Production of thrombin at a site of vascular injury could, by stimulating PGI(2) synthesis by endothelial cells adjacent to the injured area, limit the number of platelets involved in the primary hemostatic response and help to localize thrombus formation.
Journal ArticleDOI
Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells.
TL;DR: Human and bovine endothelial cells may be non-thrombogenic in vivo because they synthesize and release prostaglandin I2, a potent inhibitor of platelet aggregation, which has been identified using a two-step thin-layer radiochromatographic procedure and a synthetic prostaglandsin I 2 standard.
Journal ArticleDOI
In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use
Hans Christian Cederberg Helms,N. Joan Abbott,Malgorzata Burek,Roméo Cecchelli,Pierre Olivier Couraud,Mária A. Deli,Carola Förster,H.-J. Galla,Ignacio A. Romero,Eric V. Shusta,Matthew J. Stebbins,Elodie Vandenhaute,Babette B. Weksler,Birger Brodin +13 more
TL;DR: A review of established in vitro blood-brain barrier models with a focus on their validation regarding a set of well-established bloodbrain barrier characteristics is given in this paper, with an overview of the advantages and drawbacks of the different models described.
Journal ArticleDOI
The hCMEC/D3 cell line as a model of the human blood brain barrier
Babette B. Weksler,Ignacio A. Romero,Pierre-Olivier Couraud,Pierre-Olivier Couraud,Pierre-Olivier Couraud +4 more
TL;DR: The suitability of this brain microvascular endothelial cell line hCMEC/D3 as a human BBB model for pathogenic and drug transport studies is reviewed and critically considers its advantages and limitations.