Mohammad Haris

TL;DR: In a rat brain tumor model with blood-brain barrier disruption, intravenous glutamate injection resulted in a clear elevation of GluCEST and a similar increase in the proton magnetic resonance spectroscopy signal of glutamate, demonstrating the feasibility of using GLUCEST for mapping relative changes in glutamate concentration, as well as pH, in vivo.

TL;DR: The role of extracellular vesicles in modulating the tumor microenvironment is addressed by addressing different aspects of the bidirectional interactions among tumor and tumor-associated cells.

TL;DR: It is reported that mural cells, which surround the endothelium and are critical for blood-brain-barrier integrity, express CD19, suggesting an on-target mechanism for neurotoxicity in CD19-directed therapies and highlighting the utility of human single-cell atlases for designing immunotherapies.

TL;DR: The current studies suggest that altered barrier function may predispose or increase disease progression and therapies targeted to specifically restore the barrierfunction may provide a substitute or supplement to immunologic-based therapies.

TL;DR: It is demonstrated that MICEST detection is feasible in the human brain at ultra high fields (7 T) without exceeding the allowed limits on radiofrequency specific absorption rate and potentially opens the way to image MI in vivo and to monitor its alteration in many disease conditions.