M
Mohini Gray
Researcher at University of Edinburgh
Publications - 24
Citations - 2088
Mohini Gray is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Inflammation & Arthritis. The author has an hindex of 18, co-authored 23 publications receiving 1911 citations. Previous affiliations of Mohini Gray include Western General Hospital.
Papers
More filters
Journal ArticleDOI
Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis.
Adriano G. Rossi,Deborah A. Sawatzky,Annemieke Walker,Carol Ward,Tara A. Sheldrake,Nicola A. Riley,Alison Caldicott,Magdalena Martinez-Losa,Trevor R. Walker,Rodger Duffin,Mohini Gray,Elvira Crescenzi,Morag C. Martin,Hugh J.M. Brady,John Savill,Ian Dransfield,Christopher Haslett +16 more
TL;DR: It is shown that the CDK inhibitor R-roscovitine markedly enhances resolution of established neutrophil-dependent inflammation in carrageenan-elicited acute pleurisy, bleomycin-induced lung injury, and passively induced arthritis in mice.
Journal ArticleDOI
Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells
TL;DR: It is demonstrated that AC exert a profound influence on an adaptive immune response through the generation of CD19+ regulatory B cells, which in turn are able to influence the cytokine profile of antigen-specific effector T cells.
Journal ArticleDOI
Inflammation-induced formation of fat-associated lymphoid clusters
Cécile Bénézech,Nguyet-Thin Luu,Jennifer A. Walker,Andrei A. Kruglov,Andrei A. Kruglov,Andrei A. Kruglov,Yunhua Loo,Kyoko Nakamura,Yang Zhang,Saba Nayar,Lucy H. Jones,Adriana Flores-Langarica,Alistair McIntosh,Jennifer L. Marshall,Francesca Barone,Gurdyal S. Besra,Katherine Miles,Judith E. Allen,Mohini Gray,George Kollias,Adam F. Cunningham,David R. Withers,Kai-Michael Toellner,Nick D. Jones,Marc Veldhoen,Sergei A. Nedospasov,Sergei A. Nedospasov,Sergei A. Nedospasov,Andrew N. J. McKenzie,Jorge Caamano +29 more
TL;DR: It is found that the distribution of FALCs was heterogeneous, with the pericardium containing large numbers of these clusters, which supported and coordinated the activation of innate B cells and T cells during serosal immune responses.
Journal ArticleDOI
Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo.
Fiona Semple,Sheila Webb,Hsin-Ni Li,Hetal B. Patel,Mauro Perretti,Ian J. Jackson,Mohini Gray,Donald J. Davidson,Julia R. Dorin +8 more
TL;DR: Evidence is presented here that hBD3 lacks pro‐inflammatory activity in human and mouse primary Mϕ and that in the presence of LPS, h BD3 and the murine orthologue Defb14 effectively inhibit TNF‐α and IL‐6 accumulation implying an anti‐inflammatory function.
Journal ArticleDOI
Dying and necrotic neutrophils are anti-inflammatory secondary to the release of α-defensins
Katherine Miles,David Clarke,Wuyuan Lu,Zaneta Sibinska,Paula E. Beaumont,Donald J. Davidson,Tom A. Barr,Dominic J. Campopiano,Mohini Gray +8 more
TL;DR: How human neutrophils dying by apoptosis or necrosis release anti-inflammatory peptides, the α-defensins is described, which effectively inhibits the secretion of multiple proinflammatory cytokines and NO from macrophages, the main innate immune cell found at sites of chronic inflammation.