Lucy H. Jones

TL;DR: It is revealed that a distinct process exists in which tissue macrophages undergo rapid in situ proliferation in order to increase population density, and expansion of innate cells necessary for pathogen control or wound repair can occur without recruitment of potentially tissue-destructive inflammatory cells.

TL;DR: The data underline the vital role that CD11c+ antigen-presenting cells can play in orchestrating Th2 development against helminth infection in vivo, a response that is ordinarily balanced so as to prevent the potentially damaging production of inflammatory cytokines.

TL;DR: It was found that tranexamic acid did not reduce death from gastrointestinal bleeding and should not be used for the treatment of gastrointestinal bleeding outside the context of a randomised trial.

TL;DR: It is found that the distribution of FALCs was heterogeneous, with the pericardium containing large numbers of these clusters, which supported and coordinated the activation of innate B cells and T cells during serosal immune responses.

TL;DR: It is reported here that DCs respond to IL-4 both in vitro and in vivo by expression of multiple alternative activation markers with a different expression pattern to that of macrophages, highlighting the significant impact that IL- 4 and RELMα can have on DC activation and function in the context of either bacterial or helminth pathogens.