Monica A. De La Paz

TL;DR: Data confirm that the APOE-4 allele, or an allele in linkage disequilibrium with it, reduces the risk of age-related maculopathy and suggest that the effect of the APoe-2 allele may vary by gender, and thatAPOE-2 may confer an increased risk only to males.

TL;DR: It is suggested that ABCR is not a major genetic risk factor for AMD in their study population, and several newly described polymorphisms and variants in both the AMD and control populations are identified.

TL;DR: At least five AMD data sets provide support of genetic linkage to chromosome 10q26, and consistency and confirmation of evidence strongly suggests that this region should be the subject of further detailed genomic efforts for the disease.

TL;DR: In this article, the authors present results of incorporating five continuous covariates into their genome-wide linkage analysis of 389 microsatellite markers in 62 multiplex families: Body mass index (BMI), systolic (SBP) and diastolic (DBP) blood pressure, intraocular pressure (IOP), and pack-years of cigarette smoking.

TL;DR: This study confirmed the very high degree of ABCA4 sequence polymorphism in the general population, which makes the detection of potential disease-associated alleles particularly challenging and adds to the body of evidence suggesting that ABCA 4 is not a major susceptibility gene for this disorder.