S
Sini Kinnunen
Researcher at University of Helsinki
Publications - 15
Citations - 392
Sini Kinnunen is an academic researcher from University of Helsinki. The author has contributed to research in topics: Transcription factor & GATA4. The author has an hindex of 8, co-authored 15 publications receiving 304 citations. Previous affiliations of Sini Kinnunen include University of Oulu.
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Journal ArticleDOI
In vivo biocompatibility of porous silicon biomaterials for drug delivery to the heart.
Marja Tölli,Mónica P. A. Ferreira,Sini Kinnunen,Jaana Rysä,Ermei Mäkilä,Zoltan Szabo,Raisa Serpi,Pauli Ohukainen,Mika J. Välimäki,Alexandra Maria Rebelo Correia,Jarno Salonen,Jouni Hirvonen,Heikki Ruskoaho,Heikki Ruskoaho,Hélder A. Santos +14 more
TL;DR: The results suggest that THCPSi and TOPSi micro and nanoparticles could be applied for cardiac delivery of therapeutic agents in the future, and the PSi biomaterials might serve as a promising platform for the specific treatment of heart diseases.
Journal ArticleDOI
Drug-loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling
Mónica P. A. Ferreira,Sanjeev Ranjan,Sini Kinnunen,Alexandra Correia,Virpi Talman,Ermei Mäkilä,Ermei Mäkilä,Brianda Barrios-Lopez,Marianna Kemell,Vimalkumar Balasubramanian,Jarno Salonen,Jouni Hirvonen,Heikki Ruskoaho,Anu J. Airaksinen,Hélder A. Santos +14 more
TL;DR: In vivo single-photon emission computed tomography and autoradiography demonstrate increased accumulation of ANP-PSi nanoparticles in the ischemic heart, particularly in the endocardial layer of the left ventricle, demonstrating cardioprotective potential.
Journal ArticleDOI
In vitro and in vivo assessment of heart-homing porous silicon nanoparticles.
Mónica P. A. Ferreira,Sanjeev Ranjan,Alexandra Correia,Ermei Mäkilä,Sini Kinnunen,Hongbo Zhang,Hongbo Zhang,Mohammad-Ali Shahbazi,Patrick V. Almeida,Jarno Salonen,Heikki Ruskoaho,Anu J. Airaksinen,Jouni Hirvonen,Hélder A. Santos +13 more
TL;DR: This study functionalize undecylenic acid thermally hydrocarbonized porous silicon nanoparticles (NPs) with different targeting peptides to improve the NP's accumulation in different cardiac cells and highlights the potential of these peptide-modified nanosystems for future applications in heart diseases.
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Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5
Mika J. Välimäki,Mika J. Välimäki,Marja Tölli,Sini Kinnunen,Sini Kinnunen,Jani Aro,Raisa Serpi,Lotta Pohjolainen,Virpi Talman,Antti Poso,Heikki Ruskoaho,Heikki Ruskoaho +11 more
TL;DR: Four small molecule families are identified that either inhibit or enhance the GATA4-NKX2-5 transcriptional synergy and may provide a novel class of small molecules for modulating heart regeneration.
Journal ArticleDOI
Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4–NKX2-5 Interaction
Sini Kinnunen,Sini Kinnunen,Marja Tölli,Mika J. Välimäki,Mika J. Välimäki,Erhe Gao,Zoltan Szabo,Jaana Rysä,Mónica P. A. Ferreira,Pauli Ohukainen,Raisa Serpi,Alexandra Correia,Ermei Mäkilä,Jarno Salonen,Jouni Hirvonen,Hélder A. Santos,Heikki Ruskoaho,Heikki Ruskoaho +17 more
TL;DR: Examination of the cardiac actions of a potent inhibitor (3i-1000) of GATA4–NKX2-5 interaction in experimental models of myocardial ischemic injury and pressure overload indicates significant potential for small molecules targeting GATA 4–NKx2- 5 interaction to promote myocardian repair after myocardIAL infarction and other cardiac injuries.