M
Monica Thelestam
Researcher at Karolinska Institutet
Publications - 99
Citations - 4300
Monica Thelestam is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Toxin & Clostridium difficile toxin B. The author has an hindex of 38, co-authored 99 publications receiving 4173 citations. Previous affiliations of Monica Thelestam include Karolinska University Hospital.
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Large clostridial cytotoxins — a family of glycosyltransferases modifying small GTP-binding proteins
TL;DR: The group of large clostridial cytotoxins, which have homologous protein sequences, exert glycosyltransferase activity and modify GTP-binding proteins of the Ras-superfamily, are valuable tools for developmental and cell biologists.
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Ras, Rap, and Rac Small GTP-binding Proteins Are Targets for Clostridium sordellii Lethal Toxin Glucosylation
Michel R. Popoff,Esteban Chaves-Olarte,Emmanuel Lemichez,Emmanuel Lemichez,Christoph von Eichel-Streiber,Monica Thelestam,Pierre Chardin,Didier Cussac,Bruno Antonny,Philippe Chavrier,Gilles Flatau,M Giry,Jean de Gunzburg,Patrice Boquet,Patrice Boquet +14 more
TL;DR: LT is a glucosyltransferase that uses UDP-Glc as a cofactor to covalently modify 21-kDa proteins both in vitro and in vivo, and is thus a powerful tool to inhibit Ras function in vivo.
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The Haemophilus ducreyi Cytolethal Distending Toxin Induces Cell Cycle Arrest and Apoptosis via the DNA Damage Checkpoint Pathways
TL;DR: It is demonstrated that the effect of the Haemophilus ducreyiCDT is cell type-specific: B cell lines underwent apoptosis, epithelial cells and keratinocytes arrested exclusively in G2, whereas normal fibroblasts arrested both in G1 and G2.
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Toxins A and B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities, and surface binding to cultured cells.
TL;DR: The differing enzymatic activities of Clostridium difficile toxins turned out to be the main determinant of the difference in cytotoxic potency, whereas the different in binding contributes to a lesser degree.
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The Haemophilus ducreyi cytolethal distending toxin induces DNA double-strand breaks and promotes ATM-dependent activation of RhoA
Teresa Frisan,Ximena Cortes-Bratti,Esteban Chaves-Olarte,Esteban Chaves-Olarte,Bo Stenerlöw,Monica Thelestam +5 more
TL;DR: It is shown that a member of the CDT family causes DNA double‐strand breaks in naturally intoxicated cells, acting as a true genotoxic agent, and the existence of a novel signalling pathway for intracellularly triggered activation of the RhoA GTPase via the ATM kinase in response to DNA damage is disclosed.