P
Philippe Chavrier
Researcher at Curie Institute
Publications - 127
Citations - 18976
Philippe Chavrier is an academic researcher from Curie Institute. The author has contributed to research in topics: Endosome & Phagocytosis. The author has an hindex of 66, co-authored 123 publications receiving 17817 citations. Previous affiliations of Philippe Chavrier include National Institute for Medical Research & French Institute of Health and Medical Research.
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ARF proteins: roles in membrane traffic and beyond.
TL;DR: The understanding of the signalling pathways that are regulated by ARF1 and ARF6, two of the best characterized ARF proteins, provide a molecular context for ARF protein function in fundamental biological processes, such as secretion, endocytosis, phagocyTosis, cytokinesis, cell adhesion and tumour-cell invasion.
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Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments.
TL;DR: Findings provide evidence that members of the YPT1/SEC4 subfamily of GTP binding proteins are localized to specific exocytic and endocytic subcompartments in mammalian cells.
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rab5 controls early endosome fusion in vitro.
TL;DR: In vitro findings strongly suggest that rab5 is involved in the process of early endosome fusion, and the inhibition mediated by anti-rab5 antibodies could be overcome by complementing the assay with the cytosol containing wild-type rab5, but not with the same cytOSol depleted of rab5.
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Collective migration of an epithelial monolayer in response to a model wound
M. Poujade,Erwan Grasland-Mongrain,A. Hertzog,J. Jouanneau,Philippe Chavrier,Benoit Ladoux,A. Buguin,Pascal Silberzan +7 more
TL;DR: Dealing with Madin–Darby canine kidney cells on various surfaces, it is found that a sudden release of the available surface is sufficient to trigger collective motility, which is characterized by a duality between collective and individual behaviors.
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Force mapping in epithelial cell migration
Olivia du Roure,Alexandre Saez,Axel Buguin,Robert H. Austin,Philippe Chavrier,Pascal Siberzan,Benoit Ladoux +6 more
TL;DR: This work uses a multiple-particle tracking method to estimate the mechanical activity of cells in real time with a high-spatial resolution (down to 2 microm) imposed by the periodicity of the post array.