M
Monika A. Papworth
Researcher at Laboratory of Molecular Biology
Publications - 10
Citations - 871
Monika A. Papworth is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Zinc finger & Mitochondrial DNA. The author has an hindex of 8, co-authored 10 publications receiving 798 citations. Previous affiliations of Monika A. Papworth include University of Cambridge.
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Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA
TL;DR: It is shown that mitochondria-targeted single-chain ZFNs are efficiently transported into mitochondria in cells and bind mtDNA in a sequence-specific manner discriminating between two 12-bp long sequences that differ by a single base pair.
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Designer zinc-finger proteins and their applications
TL;DR: The applications of engineered zinc finger proteins are discussed in a context of the mechanism mediating their effect on the targeted DNA and the regulation of the expression of zinc Finger proteins and their targeting to various cellular compartments and to chromatin and non-chromatin target templates are described.
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Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes
Fuyang Li,Monika A. Papworth,Michal Minczuk,Christian Rohde,Yingying Zhang,Sergei Ragozin,Albert Jeltsch,Albert Jeltsch +7 more
TL;DR: It is shown that it is possible to direct DNA MTase activity to predetermined sites in DNA, achieve targeted gene silencing in mammalian cell lines and interfere with HSV-1 propagation.
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Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase
TL;DR: It is shown that addition of a nuclear export signal allows zinc finger chimeric enzymes to be imported into human mitochondria and a proof of principle that it is possible to target and alter mtDNA in a sequence-specific manner by using zinc finger technology.
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Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors
TL;DR: It is found that the HSV-1 replication cycle can be partially repressed by the six-finger peptide with the viral titer reduced by 90%.