Showing papers in "Gene in 2006"

TL;DR: The growth and the survival of carcinoma cells appear to be sustained by a network of receptors/ligands of the ErbB family, which is important for therapeutic approaches, since the response to anti-EGFR agents might depend on the total level of expression ofErbB receptors and ligands in tumor cells.

TL;DR: The description of the molecular characteristics of members of the DEAD-box protein family and on the enzymatic activities they possess gives insight into the regulation of ATP and RNA binding as well as in the ATPase and helicase activities.

TL;DR: A set of plasmids that can be used to express recombineering functions in some gram-negative bacteria, thereby facilitating in vivo genetic manipulations are constructed, and it is anticipated that that they will provide efficient recombination in other related gram- negative bacteria.

TL;DR: Increased appreciation of the importance of the mechanical environment in regulating and determining the structural efficacy of the skeleton makes this an exciting time for further exploration of this area.

TL;DR: It is shown that LNA-modified oligonucleotides can inhibit exogenously introduced miRNAs with high specificity using a heterologous reporter assay, and furthermore their ability to inhibit an endogenous miRNA in Drosophila melanogaster cells, leading to up-regulation of the cognate target protein.

TL;DR: Critical molecular switches, especially transcription factors, and several kinase pathways involved in osteogenic differentiation are focused on.

TL;DR: Results show for the first time Osx transcriptional regulation through the bone and cartilage related transcription factor Runx2 through the DNA element in the Osx promoter.

TL;DR: The cloning and characterization of a novel gene, lin-28 homolog B (LIN28B), which is overexpression in hepatocellular carcinoma, and its findings strongly implicate a critical role of LIN28B during development and tumorigenesis and suggest a possible novel mechanism.

TL;DR: Human alternative isoform, cryptic, skipped, and constitutive splice sites from the ALTEXTRON database were analysed regarding splice site strength, composition, GC content, position and binding site strength of polypyrimidine tract and branch site.

TL;DR: Using the semi-quantitative RT-PCR method, the tissue distribution of four additional human SDF-1 isoforms derived from alternative splicing events are determined and suggest that the novel S DF-1 splice variants encode functional proteins.

TL;DR: Novel findings indicate that this BH3-only Bcl-2 family protein has a diverse array of functions that are important to both the life and death of the cell.

TL;DR: This article reviews control of PTEN function by phosphorylation as well as by binding of lipid and protein partners and determines PI(3,4,5)P3 levels.

TL;DR: It is found that the target site of miR172 is significantly conserved in gymnosperm AP2 homologs, suggesting that regulatory mechanisms of gene expression using microRNA have been conserved over the three hundred million years since the divergence of gymnosperms and flowering plant lineages.

TL;DR: It is suggested that histone replacement and the dynamic histone modifications play important roles in regulating gene expression during erythrocytic development of the malaria parasite.

TL;DR: The expression of common MADS-box gene in tree-specific tissues suggests that the novel function combinations of a set of genes similar to those in herbaceous plants may account for the development of woody characteristics in poplar.

TL;DR: A novel transfer of functional information onto gene trees enabled us to better predict the functional origins of the endocannabinoid system.

TL;DR: The applications of engineered zinc finger proteins are discussed in a context of the mechanism mediating their effect on the targeted DNA and the regulation of the expression of zinc Finger proteins and their targeting to various cellular compartments and to chromatin and non-chromatin target templates are described.

TL;DR: Transposable elements have an important potential to contribute to pre-transcriptional gene regulation, especially by moving transcriptional signals within the genome and thus potentially leading to new gene expression patterns.

TL;DR: The beta3 gene is established as a direct target of NFATc1 in RANKL-dependent osteoclast formation using the calcineurin pathway inhibitory peptide 11R-VIVIT and involved in regulating the human beta3 integrin promoter.

TL;DR: It is suggested that Alu elements retrotranspose at a faster rate in humans than previously thought, and support the potential of AlU elements as mutagenic factors in the human genome.

TL;DR: Defining the precise roles of modifications that play in the regulation of RUNX function may reveal not only how the RUNX proteins are regulated but also how they are assembled into other regulatory machineries.

TL;DR: A large-scale expressed sequence tag (EST) sequencing project was undertaken in the black tiger shrimp Penaeus monodon to identify tissue-specific genes and genes responding to infection and heat stress and this EST database provides a useful resource for gene identification and functional genomic studies of shrimp.

TL;DR: The phylogenetic placement of the family Cranoglanididae among siluriform families was discussed and it was shown that the grouping ((Characiformes, Gymnotiformes), Siluriformes) outgroup is the most likely but there is no significant difference between this one and the other alternative hypotheses.

TL;DR: In a preliminary phylogenetic analysis based on the concatenated 7 protein coding genes, A. honmai, an apoditrysian tortricid moth joined basally within the monophyly of Lepidoptera, supporting its relationship with other more derived species including obtectomeran Ostrinia species.

TL;DR: Phylogenetic analyses showed a high degree of conservation between Arabidopsis and rice GH3 proteins and, in general, in the plant kingdom.

TL;DR: This review focuses on the regulation of fosl1 expression, stabilization and activation of the Fra-1 polypeptide and onFra-1-mediated tumorigenesis.

TL;DR: All the cone opsin genes of medaka are isolated by genome screening of a lambda-phage and bacterial artificial chromosome (BAC) libraries and it is revealed that medaka and zebrafish gained the subtype opsin subtypes independently.

TL;DR: To improve gene targeting efficiency in S. macrospora, the Deltaku70 strain was used for targeted deletion of the pheromone gene ppg2 and the phersomone receptor gene pre2, and PCR generated deletion constructs containing 1000 bp of homologous flanking sequence resulted in a drastically increased gene targeting Efficiency.

TL;DR: A mechanistic model for LCR evolution is concluded that links the pattern of LCRs within P. falciparum to its high genomic A+T content and recombination rate and enables intra-exonic recombination in a key family of cell-surface antigens.

TL;DR: The presence of all four gene families and CHARK in the rice genome suggests that a cytokinin signal is transduced by the phosphotransfer mechanism as is the case in Arabidopsis, and that rice may have an additional novel signalling pathway involving serine/threonine phosphorylation.