M
Motokazu Uchigashima
Researcher at Hokkaido University
Publications - 33
Citations - 3960
Motokazu Uchigashima is an academic researcher from Hokkaido University. The author has contributed to research in topics: Inhibitory postsynaptic potential & Neurotransmission. The author has an hindex of 23, co-authored 32 publications receiving 3554 citations.
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Journal ArticleDOI
Endocannabinoid-Mediated Control of Synaptic Transmission
TL;DR: This review aims to integrate the current understanding of functions of the endocannabinoid system, especially focusing on the control of synaptic transmission in the brain, and summarizes recent electrophysiological studies carried out on synapses of various brain regions and discusses how synaptic transmission is regulated by endoc cannabinoidoid signaling.
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The Endocannabinoid 2-Arachidonoylglycerol Produced by Diacylglycerol Lipase α Mediates Retrograde Suppression of Synaptic Transmission
Asami Tanimura,Maya Yamazaki,Yuki Hashimotodani,Motokazu Uchigashima,Shinya Kawata,Manabu Abe,Yoshihiro Kita,Kouichi Hashimoto,Kouichi Hashimoto,Takao Shimizu,Masahiko Watanabe,Kenji Sakimura,Masanobu Kano +12 more
TL;DR: This article showed that 2-arachidonoylglycerol (2-AG) produced by DGLalpha and DGLbeta enzymes mediates retrograde suppression at central synapses.
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Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum
Motokazu Uchigashima,Madoka Narushima,Masahiro Fukaya,István Katona,Masanobu Kano,Masahiko Watanabe +5 more
TL;DR: 2-AG is identified as the major endocannabinoid mediating retrograde suppression at excitatory and inhibitory synapses of MS neurons, and CB1 cannabinoid receptor, the main target of 2-AG, was present at high levels on GABAergic axon terminals of MS neuron and parvalbumin-positive interneurons and at low levels on excitatories corticostriatal afferents.
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Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor.
Takayuki Yoshida,Masahiro Fukaya,Motokazu Uchigashima,Eriko Miura,Haruyuki Kamiya,Masanobu Kano,Masahiko Watanabe +6 more
TL;DR: The results indicate that DAGLα is essentially targeted to postsynaptic spines in cerebellar and hippocampal neurons, but its fine distribution within and around spines is differently regulated between the two neurons.
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Three Types of Neurochemical Projection from the Bed Nucleus of the Stria Terminalis to the Ventral Tegmental Area in Adult Mice
Takehiro Kudo,Motokazu Uchigashima,Taisuke Miyazaki,Kohtarou Konno,Miwako Yamasaki,Yuchio Yanagawa,Masabumi Minami,Masahiko Watanabe +7 more
TL;DR: The major mode of the BST–VTA projection is GABAergic, and its activation is predicted to disinhibit VTA DAergic neurons.