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Yuki Hashimotodani
Researcher at University of Tokyo
Publications - 26
Citations - 4268
Yuki Hashimotodani is an academic researcher from University of Tokyo. The author has contributed to research in topics: Endocannabinoid system & Cannabinoid receptor. The author has an hindex of 20, co-authored 23 publications receiving 3716 citations. Previous affiliations of Yuki Hashimotodani include Kanazawa University & Osaka University.
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Journal ArticleDOI
Endocannabinoid-Mediated Control of Synaptic Transmission
TL;DR: This review aims to integrate the current understanding of functions of the endocannabinoid system, especially focusing on the control of synaptic transmission in the brain, and summarizes recent electrophysiological studies carried out on synapses of various brain regions and discusses how synaptic transmission is regulated by endoc cannabinoidoid signaling.
Journal ArticleDOI
Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics
Shuo Chen,Adam Z. Weitemier,Xiao Zeng,Linmeng He,Xiyu Wang,Yanqiu Tao,Arthur J Huang,Yuki Hashimotodani,Masanobu Kano,Hirohide Iwasaki,Laxmi Kumar Parajuli,Shigeo Okabe,Daniel Boon Loong Teh,Angelo H. All,Iku Tsutsui-Kimura,Kenji F. Tanaka,Xiaogang Liu,Xiaogang Liu,Thomas J. McHugh,Thomas J. McHugh +19 more
TL;DR: It is demonstrated that molecularly tailored UCNPs can serve as optogenetic actuators of transcranial NIR light to stimulate deep brain neurons and evoked dopamine release from genetically tagged neurons in the ventral tegmental area and triggered memory recall.
Journal ArticleDOI
The Endocannabinoid 2-Arachidonoylglycerol Produced by Diacylglycerol Lipase α Mediates Retrograde Suppression of Synaptic Transmission
Asami Tanimura,Maya Yamazaki,Yuki Hashimotodani,Motokazu Uchigashima,Shinya Kawata,Manabu Abe,Yoshihiro Kita,Kouichi Hashimoto,Kouichi Hashimoto,Takao Shimizu,Masahiko Watanabe,Kenji Sakimura,Masanobu Kano +12 more
TL;DR: This article showed that 2-arachidonoylglycerol (2-AG) produced by DGLalpha and DGLbeta enzymes mediates retrograde suppression at central synapses.
Journal ArticleDOI
Phospholipase Cβ Serves as a Coincidence Detector through Its Ca2+ Dependency for Triggering Retrograde Endocannabinoid Signal
Yuki Hashimotodani,Takako Ohno-Shosaku,Hiroshi Tsubokawa,Hidenori Ogata,Ken Emoto,Takashi Maejima,Kenji Araishi,Hee-Sup Shin,Masanobu Kano +8 more
TL;DR: PLCbeta1 serves as a coincidence detector through its Ca(2+) dependency for endocannabinoid release in hippocampal neurons and is detected by phospholipase Cbeta1 in hippocampusal neurons.
Journal ArticleDOI
Synaptically Driven Endocannabinoid Release Requires Ca2+-Assisted Metabotropic Glutamate Receptor Subtype 1 to Phospholipase C β4 Signaling Cascade in the Cerebellum
Takashi Maejima,Saori Oka,Yuki Hashimotodani,Takako Ohno-Shosaku,Atsu Aiba,Dianqing Wu,Keizo Waku,Takayuki Sugiura,Masanobu Kano +8 more
TL;DR: The results strongly suggest that under physiological conditions, excitatory synaptic inputs to PCs activate the Ca2+-assisted mGluR1-PLCβ4 cascade, and thereby produce 2-AG, which retrogradely modulates synaptic transmission to PCs.