M
Muhammad Safdar
Researcher at Gomal University
Publications - 15
Citations - 145
Muhammad Safdar is an academic researcher from Gomal University. The author has contributed to research in topics: Chemistry & RNA. The author has an hindex of 4, co-authored 12 publications receiving 39 citations. Previous affiliations of Muhammad Safdar include Abbottabad University of Science and Technology.
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Journal ArticleDOI
The SARS-CoV-2 B.1.618 variant slightly alters the spike RBD-ACE2 binding affinity and is an antibody escaping variant: a computational structural perspective
Abbas Khan,J. J. Gui,W. Ahmad,I. Haq,M. Shahid,Azhar Abbas Khan,Abdullah Shah,L. Ali,Zeeshan Anwar,Muhammad Safdar,J. Abubaker,N. N. Uddin,L. Q. Cao,Dong-Qing Wei,A. Mohammad +14 more
TL;DR: Insight is provided into the binding and structural-dynamics changes resulting from novel mutations in the RBD and NTD and the need for further in vitro and in vivo studies is suggested to facilitate the development of possible therapies for new variants of SARS-CoV-2.
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Chitosan-Coated 5-Fluorouracil Incorporated Emulsions as Transdermal Drug Delivery Matrices.
Taif Ali Khan,Abul Kalam Azad,Shivkanya Fuloria,Asif Nawaz,Vetriselvan Subramaniyan,Muhammad Akhlaq,Muhammad Safdar,Kathiresan V. Sathasivam,Mahendran Sekar,Omji Porwal,Dhanalekshmi Unnikrishnan Meenakshi,Rishabha Malviya,Mireia Mallandrich Miret,Ajay Mendiratta,Neeraj Kumar Fuloria +14 more
TL;DR: In this paper, the authors developed emulsions encapsulated by chitosan on the outer surface of a nano droplet containing 5-fluorouracil (5-FU) as a model drug.
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Methotrexate-Loaded Gelatin and Polyvinyl Alcohol (Gel/PVA) Hydrogel as a pH-Sensitive Matrix.
Muhammad Akhlaq,Abul Kalam Azad,Inam Ullah,Asif Nawaz,Muhammad Safdar,Tanima Bhattacharya,A. B. M. Helal Uddin,Syed Atif Abbas,Allan Mathews,Sukalyan Kumar Kundu,Mireia Mallandrich Miret,H. C. Ananda Murthy,H.P. Nagaswarupa +12 more
TL;DR: In this paper, the authors formulated and evaluated Gel/PVA hydrogels as a pH-sensitive matrix to deliver methotrexate (MTX) to colon using an acidic (pH 1.2) and phosphate buffer (PBS) media.
Journal Article
A Nexus between Working Capital Management and Profitability: A Case Study of Pharmaceutical Sector in Pakistan
TL;DR: In this paper, the impact of working capital management on financial outcomes of pharmaceutical sector in Pakistan is discussed and the correlation analysis indicates that there is negative relationship between working capital and profitability which is significant at 1% level.
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Genome-wide screening of vaccine targets prioritization and reverse vaccinology aided design of peptides vaccine to enforce humoral immune response against Campylobacter jejuni.
Adnan Zeb,Syed Shujait Ali,Abul Kalam Azad,Muhammad Safdar,Zeeshan Anwar,Muhammad Suleman,N. Nizam-Uddin,Abbas Khan,Dong-Qing Wei +8 more
TL;DR: In this paper, the authors used a subtractive proteomics pipeline to prioritize essential proteins, which impart a critical role in virulence, replication and survival, and selected five proteins, i.e. Single-stranded DNA-binding protein, UPF0324 membrane protein Cj0999c, DNA translocase FtsK, 50S ribosomal protein L22, and 50S Ribosomal Protein L1, for vaccine design.