Muhammet Tanc

TL;DR: All tested bromophenol derivatives exhibited excellent inhibitory effects, in the low nanomolar range, with Ki values in the range of 0.97-12.14 nM against hCA II, whereas they were low micromolar inhibitors against h CA IX and XII.

TL;DR: A series of novel sulfamides incorporating the dopamine scaffold may lead to inhibitors targeting medicinally relevant CA isoforms with potential applications as antiepileptic, antiobesity antitumor agents or anti-infective.

TL;DR: 6-Substituted sulfocoumarins bearing the carboxamido, trimethylammonium as well as the cyano and methoxy moieties with interesting inhibitory activity/selectivity against the tumor associated carbonic anhydrase isoforms hCA IX and XII reveal effective cytotoxic effects after 72 h of incubation in both normoxic and hypoxic conditions.

TL;DR: Docking studies revealed that the NO2 group of both compounds participate in interactions with Asp132 within the hCA IX active site, and with residues Lys67 and Asp130 in hCA XII, respectively.

TL;DR: Compounds from this series showed low nanomolar hCA II inhibitory properties, and inhibited the mitochondrial isoform hCA VA with KIs in the range of 91-9960 nM, but were ineffective as hCA I, IX and XII inhibitors.