M
Muhammet Tanc
Researcher at University of Florence
Publications - 45
Citations - 1599
Muhammet Tanc is an academic researcher from University of Florence. The author has contributed to research in topics: Carbonic anhydrase & Carbonic Anhydrase I. The author has an hindex of 23, co-authored 44 publications receiving 1373 citations.
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Journal ArticleDOI
Synthesis and carbonic anhydrase isoenzymes I, II, IX, and XII inhibitory effects of dimethoxybromophenol derivatives incorporating cyclopropane moieties.
Murat Boztas,Yasin Çetinkaya,Meryem Topal,İlhami Gülçin,İlhami Gülçin,Abdullah Menzek,Ertan Şahin,Muhammet Tanc,Claudiu T. Supuran +8 more
TL;DR: All tested bromophenol derivatives exhibited excellent inhibitory effects, in the low nanomolar range, with Ki values in the range of 0.97-12.14 nM against hCA II, whereas they were low micromolar inhibitors against h CA IX and XII.
Journal ArticleDOI
Synthesis and carbonic anhydrase inhibitory properties of sulfamides structurally related to dopamine.
Kadir Aksu,Meryem Nar,Muhammet Tanc,Daniela Vullo,İlhami Gülçin,Süleyman Göksu,Ferhan Tümer,Claudiu T. Supuran +7 more
TL;DR: A series of novel sulfamides incorporating the dopamine scaffold may lead to inhibitors targeting medicinally relevant CA isoforms with potential applications as antiepileptic, antiobesity antitumor agents or anti-infective.
Journal ArticleDOI
6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells.
Aiga Grandane,Muhammet Tanc,Lorenzo Di Cesare Mannelli,Fabrizio Carta,Carla Ghelardini,Raivis Žalubovskis,Claudiu T. Supuran +6 more
TL;DR: 6-Substituted sulfocoumarins bearing the carboxamido, trimethylammonium as well as the cyano and methoxy moieties with interesting inhibitory activity/selectivity against the tumor associated carbonic anhydrase isoforms hCA IX and XII reveal effective cytotoxic effects after 72 h of incubation in both normoxic and hypoxic conditions.
Journal ArticleDOI
Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII.
Hany S. Ibrahim,Sahar M. Abou-Seri,Muhammet Tanc,Mahmoud M. Elaasser,Hatem A. Abdel-Aziz,Claudiu T. Supuran +5 more
TL;DR: Docking studies revealed that the NO2 group of both compounds participate in interactions with Asp132 within the hCA IX active site, and with residues Lys67 and Asp130 in hCA XII, respectively.
Journal ArticleDOI
7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors.
TL;DR: Compounds from this series showed low nanomolar hCA II inhibitory properties, and inhibited the mitochondrial isoform hCA VA with KIs in the range of 91-9960 nM, but were ineffective as hCA I, IX and XII inhibitors.