M
Muriel Meier
Researcher at French Institute of Health and Medical Research
Publications - 8
Citations - 1234
Muriel Meier is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: BSCL2 & Congenital generalized lipodystrophy. The author has an hindex of 6, co-authored 7 publications receiving 1147 citations. Previous affiliations of Muriel Meier include Pierre-and-Marie-Curie University.
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Journal ArticleDOI
Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13.
Jocelyne Magré,Marc Delepine,Eliane Khallouf,Tobias Gedde-Dahl,Lionel Van Maldergem,Eric M. Sobel,Jeanette C. Papp,Muriel Meier,André Mégarbané,A. Bachy,Alain Verloes,F. H. D'abronzo,E. Seemanova,Roger Assan,N. Baudic,Bourut C,Paul Czernichow,Frédéric Huet,Florin Grigorescu,M. De Kerdanet,Didier Lacombe,Philippe Labrune,M. Lanza,H. Loret,Fumihiko Matsuda,J. Navarro,A. Nivelon-Chevalier,Meraida Polak,J.-J. Robert,P. Tric,N. Tubiana-Rufi,Corinne Vigouroux,Jean Weissenbach,S. Savasta,J. A. Maassen,O. Trygstad,P. Bogalho,P. Freitas,J. L. Medina,F. Bonnicci,Barry I Joffe,G. Loyson,Vanessa R. Panz,Frederick J. Raal,Stephen O'Rahilly,T. Stephenson,C R Kahn,Mark Lathrop,Jacqueline Capeau +48 more
TL;DR: A genome screen of nine BSCL families from two geographical clusters revealed mutations in a gene homologous to the murine guanine nucleotide-binding protein, γ3-linked gene (Gng3lg) in all BSCL2-linked families, of general importance for understanding the molecular mechanisms underlying regulation of body fat distribution and insulin resistance.
Journal ArticleDOI
Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy.
Chong Ae Kim,Marc Delepine,Emilie Boutet,Haquima El Mourabit,Soazig Le Lay,Muriel Meier,Mona Nemani,Etienne Bridel,Claudia da Costa Leite,Débora Romeo Bertola,Robert K. Semple,Stephen O'Rahilly,Isabelle Dugail,Jacqueline Capeau,Mark Lathrop,Jocelyne Magré +15 more
TL;DR: Findings identify CAV1 as a new BSCL-related gene and support a critical role for caveolins in human adipocyte function, which is a key structural component of plasma membrane caveolae, and Cav1-deficient mice display progressive loss of adipose tissue and insulin resistance.
Journal ArticleDOI
Human peroxisome proliferator-activated receptor-gamma2: genetic mapping, identification of a variant in the coding sequence, and exclusion as the gene responsible for lipoatrophic diabetes.
Corinne Vigouroux,Lluis Fajas,Eliane Khallouf,Muriel Meier,G Gyapay,Olivier Lascols,Johan Auwerx,Jean Weissenbach,Jacqueline Capeau,Jocelyne Magré +9 more
TL;DR: A large number of patients with type 2 diabetes are at high-risk for developing central giant cell granuloma, and this research highlights the need to understand more fully the mechanisms leading to this condition.
Journal ArticleDOI
Prevalence of mutations in AGPAT2 among human lipodystrophies.
Jocelyne Magré,Marc Delepine,Lionel Van Maldergem,Jean-Jacques Robert,J. Antonie Maassen,Muriel Meier,Vanessa R. Panz,Chong Ae Kim,Nadia Tubiana-Rufi,Paul Czernichow,E. Seemanova,Charles R. Buchanan,Didier Lacombe,Corinne Vigouroux,Olivier Lascols,C. Ronald Kahn,Jacqueline Capeau,Mark Lathrop +17 more
TL;DR: Because mutations are found in 92 of the 94 BSCL patients studied, the seipin gene and AGPAT2 are the two major genes involved in the etiology of BSCL, and they are confined to the BSCL phenotype.
Journal ArticleDOI
Leptin therapy for partial lipodystrophy linked to a PPAR‐γ mutation
Jean-Marc Guettier,Jean Y. Park,Elaine Cochran,Christine Poitou,Arnaud Basdevant,Muriel Meier,Muriel Meier,Karine Clément,Jocelyne Magré,Jocelyne Magré,Phillip Gorden +10 more
TL;DR: This is the first report to detail the clinical response of a patient with PL due to a PPARG mutation treated with r‐metHuLeptin.