Murray Leikis

TL;DR: Integrated molecular network modelling revealed differential DNA methylation and miRNA expression changes occur in skeletal muscle in response to chronic exercise training that are most pronounced with endurance training and topographically associated with functional metabolic and microvascular plasticity relevant to diabetes rehabilitation.

TL;DR: This study did not demonstrate an improvement in HbA1c with exercise in morbidly obese Polynesian people, and future investigations involving exercise regimens that are more practicable and which involve greater frequency and duration of training may be required to induce significant and clinically meaningful adaptations in this unique diabetes population.

TL;DR: The approach to cultural consultation could be considered by researchers undertaking trials in this and other ethnic populations suffering an extreme burden of T2DM, including indigenous Australians and Americans.

TL;DR: Exercise, regardless of specific modality, can improve many aspects of QoL in this population of indigenous Polynesian peoples with type 2 diabetes and visceral obesity.

TL;DR: In this paper, the authors show that metabolic acidosis may affect mitochondrial biogenesis, with divergent responses in resting and post-exercise skeletal muscle, and they also show that the early postexercise increase of peroxisome proliferator-activated receptor co-activator 1α (PGC-1α), citrate synthase, cytochome c and FOXO1 was not significant (P = 0.08).