M
Myron F. Goodman
Researcher at University of Southern California
Publications - 272
Citations - 21337
Myron F. Goodman is an academic researcher from University of Southern California. The author has contributed to research in topics: DNA polymerase & DNA replication. The author has an hindex of 79, co-authored 267 publications receiving 20660 citations. Previous affiliations of Myron F. Goodman include City of Hope National Medical Center & Albert Einstein College of Medicine.
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Journal ArticleDOI
The importance of repairing stalled replication forks
Michael M. Cox,Myron F. Goodman,Kenneth N. Kreuzer,David J. Sherratt,Steven J. Sandler,Kenneth J. Marians +5 more
TL;DR: The bacterial SOS response to unusual levels of DNA damage has been recognized and studied for several decades, but pathways for re-establishing inactivated replication forks under normal growth conditions have received far less attention.
Journal ArticleDOI
The Y-Family of DNA Polymerases
Haruo Ohmori,Errol C. Friedberg,Robert P. P. Fuchs,Myron F. Goodman,Fumio Hanaoka,David C. Hinkle,Thomas A. Kunkel,Christopher W. Lawrence,Zvi Livneh,Takehiko Nohmi,Louise Prakash,Satya Prakash,Takeshi Todo,Graham C. Walker,Zhigang Wang,Roger Woodgate +15 more
TL;DR: The unrooted phylogenetic tree shown in Figure 1 shows the progression of tree-like structures formed over time in the presence of E.coli and shows the relationships between E. Coli and Tournaisian trees.
Journal ArticleDOI
Error-prone repair DNA polymerases in prokaryotes and eukaryotes.
TL;DR: This review is devoted primarily to a discussion of Y-family polymerase members that exhibit error-prone behavior, which poses challenging questions about their roles in targeting and trafficking.
Journal ArticleDOI
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
TL;DR: It is shown that AID catalyzes deamination of dC residues on single-stranded DNA in vitro but not on double-Stranded DNA, RNA–DNA hybrids, or RNA, suggesting a targeting mechanism for this enigmatic enzyme during somatic hypermutation.
Journal ArticleDOI
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation.
TL;DR: It is shown in vitro that AID-catalysed C deaminations occur preferentially on 5′ WRC sequences in accord with SHM spectra observed in vivo, and AID exhibits a 15-fold preference for C deamination on the non-transcribed DNA strand exposed by RNA polymerase than the transcribed strand protected as a RNA–DNA hybrid.