Z
Zhigang Wang
Researcher at University of Kentucky
Publications - 59
Citations - 6362
Zhigang Wang is an academic researcher from University of Kentucky. The author has contributed to research in topics: DNA polymerase & Nucleotide excision repair. The author has an hindex of 39, co-authored 59 publications receiving 6208 citations. Previous affiliations of Zhigang Wang include University of Texas Southwestern Medical Center & University of Miami.
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Journal ArticleDOI
The Y-Family of DNA Polymerases
Haruo Ohmori,Errol C. Friedberg,Robert P. P. Fuchs,Myron F. Goodman,Fumio Hanaoka,David C. Hinkle,Thomas A. Kunkel,Christopher W. Lawrence,Zvi Livneh,Takehiko Nohmi,Louise Prakash,Satya Prakash,Takeshi Todo,Graham C. Walker,Zhigang Wang,Roger Woodgate +15 more
TL;DR: The unrooted phylogenetic tree shown in Figure 1 shows the progression of tree-like structures formed over time in the presence of E.coli and shows the relationships between E. Coli and Tournaisian trees.
Journal ArticleDOI
p53 modulation of TFIIH-associated nucleotide excision repair activity.
Xin Wei Wang,Heidi Yeh,L. Schaeffer,Richard Roy,V. Moncollin,Jean-Marc Egly,Zhigang Wang,Errol C. Friedberg,Michele K. Evans,Bonita G. Taffe,Vilhelm A. Bohr,Geert Weeda,Jan H.J. Hoeijmakers,Kathleen Forrester,Chris Harris +14 more
TL;DR: It is found that wild–type, but not Arg273His mutant p53 inhibits XPD (Rad3) and XPB DNA helicase activities and repair of UV–induced dimers is slower in Li–Fraumeni syndrome cells (heterozygote p53 mutant) than in normal human cells, indicating that p53 may play a direct role in modulating nucleotide excision repair pathways.
Journal ArticleDOI
Eukaryotic DNA polymerases: proposal for a revised nomenclature.
Peter M. J. Burgers,Eugene V. Koonin,Elspeth A. Bruford,Luis Blanco,Kenneth C. Burtis,Michael F. Christman,William C. Copeland,Errol C. Friedberg,Fumio Hanaoka,David C. Hinkle,Christopher W. Lawrence,Makoto Nakanishi,Haruo Ohmori,Louise Prakash,Satya Prakash,Claude Agnes Reynaud,Akio Sugino,Takeshi Todo,Zhigang Wang,Jean Claude Weill,Roger Woodgate +20 more
TL;DR: This work presents a meta-anatomy of DNA replication and its role in disease and Immunity that has never been seen before in the clinic and shows clear patterns in the immune response to various types of viruses.
Journal ArticleDOI
Different forms of TFIIH for transcription and DNA repair: Holo-TFIIH and a nucleotide excision repairosome
Jesper Q. Svejstrup,Zhigang Wang,William J Feave,Xiahua Wu,David A. Bushnell,Thomas F. Donahue,Errol C. Friedberg,Roger D. Kornberg +7 more
TL;DR: Yeast TFIIH that is highly active in nucleotide excision repair (NER) lacks the kinase complex and instead contains the products of all other genes known to be required for NER in yeast: RAD1, RAD2, RAD4, RAD10, and RAD14.
Journal ArticleDOI
Error-free and error-prone lesion bypass by human DNA polymerase κ in vitro
Yanbin Zhang,Fenghua Yuan,Xiaohua Wu,Mu Wang,Mu Wang,Olga Rechkoblit,Olga Rechkoblit,John-Stephen Taylor,John-Stephen Taylor,Nicholas E. Geacintov,Nicholas E. Geacintov,Zhigang Wang +11 more
TL;DR: It is shown that human Polκ is a novel lesion bypass polymerase in vitro and its response to damaged DNA templates suggests that Polκ plays an important role in both error-free and errorproneLesion bypass in humans.