F
Fumio Hanaoka
Researcher at Gakushuin University
Publications - 399
Citations - 27113
Fumio Hanaoka is an academic researcher from Gakushuin University. The author has contributed to research in topics: DNA polymerase & DNA replication. The author has an hindex of 84, co-authored 392 publications receiving 26084 citations. Previous affiliations of Fumio Hanaoka include Tohoku University & Kyoto University.
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Journal ArticleDOI
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta.
Chikahide Masutani,Rika Kusumoto,Rika Kusumoto,Ayumi Yamada,Naoshi Dohmae,Masayuki Yokoi,Mayumi Yuasa,Marito Araki,Shigenori Iwai,Koji Takio,Fumio Hanaoka +10 more
TL;DR: Recombinant human DNA polymerase η corrects the inability of XP-V cell extracts to carry out DNA replication by bypassing thymine dimers on damaged DNA, indicating that DNA polymerases η could be the XPV gene product.
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Xeroderma Pigmentosum Group C Protein Complex Is the Initiator of Global Genome Nucleotide Excision Repair
Kaoru Sugasawa,Jessica M. Y. Ng,Chikahide Masutani,Shigenori Iwai,Peter J. van der Spek,André P. M. Eker,Fumio Hanaoka,Dirk Bootsma,Jan H.J. Hoeijmakers +8 more
TL;DR: A novel DNA damage recognition-competition assay is used to identify XPC-HR23B as the earliest damage detector to initiate NER: it acts before the known damage-binding protein XPA, providing a plausible explanation for the extreme damage specificity exhibited by global genome repair.
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The Y-Family of DNA Polymerases
Haruo Ohmori,Errol C. Friedberg,Robert P. P. Fuchs,Myron F. Goodman,Fumio Hanaoka,David C. Hinkle,Thomas A. Kunkel,Christopher W. Lawrence,Zvi Livneh,Takehiko Nohmi,Louise Prakash,Satya Prakash,Takeshi Todo,Graham C. Walker,Zhigang Wang,Roger Woodgate +15 more
TL;DR: The unrooted phylogenetic tree shown in Figure 1 shows the progression of tree-like structures formed over time in the presence of E.coli and shows the relationships between E. Coli and Tournaisian trees.
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Azathioprine and UVA Light Generate Mutagenic Oxidative DNA Damage
Peter O'Donovan,C. M. Perrett,Xiaohong Zhang,Beatriz Montaner,Yao-Zhong Xu,Catherine A. Harwood,Jane M. McGregor,Susan L. Walker,Fumio Hanaoka,Peter Karran +9 more
TL;DR: It is demonstrated that biologically relevant doses of ultraviolet A (UVA) generate ROS in cultured cells with 6- TG–substituted DNA and that 6-TG and UVA are synergistically mutagenic.
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UV-Induced Ubiquitylation of XPC Protein Mediated by UV-DDB-Ubiquitin Ligase Complex
Kaoru Sugasawa,Yuki Okuda,Masafumi Saijo,Ryotaro Nishi,Noriyuki Matsuda,Gilbert Chu,Toshio Mori,Shigenori Iwai,Keiji Tanaka,Kiyoji Tanaka,Fumio Hanaoka +10 more
TL;DR: It is shown that XPC undergoes reversible ubiquitylation upon UV irradiation of cells and that this depends on the presence of functional UV-DDB activity, which strongly suggest that ubiquitylated plays a critical role in the transfer of the UV-induced lesion from UV- DDB to XPC.