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Myung-Hee Kwon

Researcher at Ajou University

Publications -  71
Citations -  1528

Myung-Hee Kwon is an academic researcher from Ajou University. The author has contributed to research in topics: Antibody & Nucleic acid. The author has an hindex of 22, co-authored 68 publications receiving 1403 citations. Previous affiliations of Myung-Hee Kwon include Chonnam National University & Sungkyunkwan University.

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Journal ArticleDOI

STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cells

Sarah Yoon, +8 more
- 16 Nov 2010 - 
TL;DR: It is found for the first time that JAK2/STAT3 was activated in HeLa cells when they were starved or treated with rapamycin, indicating that the autophagic process in cancer cells can contribute to their survival by JAk2/ STAT3 activation and subsequent secretion of growth factors.
Journal ArticleDOI

Heavy and Light Chain Variable Single Domains of an Anti-DNA Binding Antibody Hydrolyze Both Double- and Single-stranded DNAs without Sequence Specificity

Young-Rim Kim, +9 more
- 02 Jun 2006 - 
TL;DR: The results demonstrate single domain Abs with DNase activities for the first time, which might provide new insights into substrate recognition and catalytic mechanisms of anti-DNA Abs.
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Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death.

Kyung Jin Park, +6 more
- 15 May 2009 - 
TL;DR: It is suggested that DR5-stimulated JNK activation and its consequent fluxes into the pro-autophagic signaling pathways contribute to the autophagic cell death in cancer cells.
Journal ArticleDOI

A human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and TRAIL-resistant cancer cells.

Kyung-Jin Park, +9 more
- 01 Aug 2007 - 
TL;DR: The results reveal a novel TR2-mediated signaling pathway triggering autophagic cell death and provides a new strategy for the elimination of cancer cells, including TRAIL-resistant tumors, through nonapoptotic cell death.
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A nucleic acid-hydrolyzing antibody penetrates into cells via caveolae-mediated endocytosis, localizes in the cytosol and exhibits cytotoxicity.

Joong-Soon Jang, +6 more
- 14 Apr 2009 - 
TL;DR: It is demonstrated that 3D8 scFv has a unique intracellular trafficking route of localizing in the cytosol, thereby exhibiting cytotoxicity due to its nuclease activity.