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N. Martin Young
Researcher at National Research Council
Publications - 62
Citations - 3822
N. Martin Young is an academic researcher from National Research Council. The author has contributed to research in topics: Campylobacter jejuni & Antigen. The author has an hindex of 30, co-authored 62 publications receiving 3661 citations. Previous affiliations of N. Martin Young include John Radcliffe Hospital.
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Journal ArticleDOI
Structure of the N-Linked Glycan Present on Multiple Glycoproteins in the Gram-negative Bacterium, Campylobacter jejuni
N. Martin Young,Jean-Robert Brisson,John F. Kelly,David C. Watson,Luc Tessier,Patricia Lanthier,Harold C. Jarrell,Nicolas Cadotte,Frank St. Michael,Erika Aberg,Christine M. Szymanski +10 more
TL;DR: Comparison of thepgl locus with that of Neisseria meningitidissuggested that most of the homologous genes are probably involved in the biosynthesis of bacillosamine, and at least 22 glycoproteins were identified.
Journal ArticleDOI
Definition of the bacterial N-glycosylation site consensus sequence.
Michael Kowarik,N. Martin Young,Shin Numao,Benjamin L. Schulz,Isabelle Hug,Nico Callewaert,Dominic C Mills,David C. Watson,Marcela Hernandez,John F. Kelly,Michael Wacker,Markus Aebi +11 more
TL;DR: Bacterial N‐glycosylation site selection is more specific than the eukaryotic equivalent with respect to the polypeptide acceptor sequence.
Journal ArticleDOI
The genetic bases for the variation in the lipo-oligosaccharide of the mucosal pathogen, Campylobacter jejuni. Biosynthesis of sialylated ganglioside mimics in the core oligosaccharide
Michel Gilbert,Marie-France Karwaski,Stéphane Bernatchez,N. Martin Young,Eduardo N. Taboada,J.J. Michniewicz,Anna-Maria Cunningham,Warren W. Wakarchuk +7 more
TL;DR: Compared the lipo-oligosaccharide biosynthesis loci from 11 Campylobacter jejunistrains expressing a total of 8 different ganglioside mimics in their LOS outer cores, at least five distinct mechanisms that allow C. jejuni to vary the structure of the LOSouter core are identified.
Journal ArticleDOI
Biosynthesis of ganglioside mimics in Campylobacter jejuni OH4384. Identification of the glycosyltransferase genes, enzymatic synthesis of model compounds, and characterization of nanomole amounts by 600-mhz (1)h and (13)c NMR analysis.
Michel Gilbert,Jean-Robert Brisson,Marie-France Karwaski,J.J. Michniewicz,Anna-Maria Cunningham,Yuyang Wu,N. Martin Young,Warren W. Wakarchuk +7 more
TL;DR: Two strategies for the cloning of four genes responsible for the biosynthesis of the GT1a ganglioside mimic in the lipooligosaccharide (LOS) of a bacterial pathogen,Campylobacter jejuni OH4384, which has been associated with Guillain-Barré syndrome are applied.
Journal ArticleDOI
Quantitative Analysis of Bacterial Toxin Affinity and Specificity for Glycolipid Receptors by Surface Plasmon Resonance
TL;DR: In this paper, surface plasmon resonance (SPR) was used for real-time analysis of toxin binding under conditions that mimic the natural cell surface venue of these interactions and without any requirement for labeling of toxin or receptor.