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Nadège Dubourdieu
Researcher at French Institute of Health and Medical Research
Publications - 4
Citations - 134
Nadège Dubourdieu is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Hippocampal formation & Dentate gyrus. The author has an hindex of 3, co-authored 4 publications receiving 72 citations. Previous affiliations of Nadège Dubourdieu include University of Bordeaux.
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Selective dentate gyrus disruption causes memory impairment at the early stage of experimental multiple sclerosis.
Vincent Planche,Aude Panatier,Bassem Hiba,Eva-Gunnel Ducourneau,Gérard Raffard,Nadège Dubourdieu,Marlène Maitre,Thierry Leste-Lasserre,Bruno Brochet,Vincent Dousset,Aline Desmedt,Stéphane H. R. Oliet,Thomas Tourdias +12 more
TL;DR: It is concluded that early memory impairment in EAE is due to a selective disruption of the dentate gyrus associated with microglia activation, which opens new pathophysiological, imaging, and therapeutic perspectives forMemory impairment in multiple sclerosis.
Journal ArticleDOI
Deciphering the microstructure of hippocampal subfields with in vivo DTI and NODDI: Applications to experimental multiple sclerosis.
Amandine Crombé,Vincent Planche,Gérard Raffard,Julien Bourel,Nadège Dubourdieu,Aude Panatier,Hikaru Fukutomi,Vincent Dousset,Stéphane H. R. Oliet,Bassem Hiba,Thomas Tourdias +10 more
TL;DR: NODDI maps can help to highlight the internal microanatomy of the hippocampus but NODDI still presents limitations in grey matter as it failed to capture selective dendritic alterations occurring at early stages of a neurodegenerative disease such as multiple sclerosis, whereas DTI maps were significantly altered.
Journal ArticleDOI
Aquaporin-4 Surface Trafficking Regulates Astrocytic Process Motility and Synaptic Activity in Health and Autoimmune Disease
Silvia Ciappelloni,Silvia Ciappelloni,Silvia Ciappelloni,Delphine Bouchet,Delphine Bouchet,Nadège Dubourdieu,Nadège Dubourdieu,Eric Boué-Grabot,Eric Boué-Grabot,Blanka Kellermayer,Blanka Kellermayer,Constance Manso,Constance Manso,Romain Marignier,Stéphane H. R. Oliet,Stéphane H. R. Oliet,Thomas Tourdias,Thomas Tourdias,Laurent Groc,Laurent Groc +19 more
TL;DR: It emerges that the membrane dynamics of AQP4 isoform regulate brain cell assemblies in health and autoimmune brain disease targeting AQP3 and human autoantibodies directed against AQp4 from neuromyelitis optica patients impaired AQP 4-M23 dynamic distribution and, consequently, astrocyte process and synaptic activity.
Journal ArticleDOI
Complement C3 mediates early hippocampal neurodegeneration and memory impairment in experimental multiple sclerosis.
Julien Bourel,Vincent Planche,Nadège Dubourdieu,Aymeric Oliveira,Alexandra Séré,Eva-Gunnel Ducourneau,Marion Tible,Marlène Maitre,Thierry Leste-Lasserre,Agnès Nadjar,Aline Desmedt,Philippe Ciofi,Stéphane H. R. Oliet,Aude Panatier,Thomas Tourdias +14 more
TL;DR: In early-stage experimental encephalomyelitis (EAE) female mice, the expression level of molecules involved in microglia-neuron interactions within the dentate gyrus and found overexpression of genes of the complement pathway as discussed by the authors.