L
Laurent Groc
Researcher at Centre national de la recherche scientifique
Publications - 129
Citations - 9359
Laurent Groc is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Glutamate receptor & Synaptic plasticity. The author has an hindex of 46, co-authored 123 publications receiving 7966 citations. Previous affiliations of Laurent Groc include Henry Ford Health System & University of Bordeaux.
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Journal ArticleDOI
Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists
Thomas Papouin,Laurent Ladépêche,Laurent Ladépêche,Jérôme Ruel,Jérôme Ruel,Silvia Sacchi,Marilyne Labasque,Marwa Hanini,Laurent Groc,Laurent Groc,Loredano Pollegioni,Jean-Pierre Mothet,Stéphane H. R. Oliet,Stéphane H. R. Oliet +13 more
TL;DR: It is demonstrated that long-term potentiation and NMDA-induced neurotoxicity rely on synaptic NMDARs only, and long- term depression requires both synaptic and extrasynaptic receptors.
Journal ArticleDOI
The Interaction between Stargazin and PSD-95 Regulates AMPA Receptor Surface Trafficking
TL;DR: It is shown, using single quantum dot and FRAP imaging in live hippocampal neurons, that exchange of AMPAR by lateral diffusion between extrasynaptic and synaptic sites mostly depends on the interaction of Stargazin with PSD-95 and not upon the GluR2 AMPAR subunit C terminus.
Journal ArticleDOI
Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors.
Laurent Groc,Martin Heine,Laurent Cognet,Kieran Brickley,F. Anne Stephenson,Brahim Lounis,Daniel Choquet +6 more
TL;DR: Different lateral mobilities for AMPARs and NMDARs are found: changes in neuronal activity modified AMPAR but not NMDar mobility, whereas protein kinase C activation modified both.
Journal ArticleDOI
Surface Mobility of Postsynaptic AMPARs Tunes Synaptic Transmission
Martin Heine,Laurent Groc,Renato Frischknecht,Jean-Claude Béïque,Brahim Lounis,Gavin Rumbaugh,Richard L. Huganir,Laurent Cognet,Daniel Choquet +8 more
TL;DR: It is shown that AMPAR lateral diffusion, observed in both intact hippocampi and cultured neurons, allows fast exchange of desensitized receptors with naïve functional ones within or near the postsynaptic density, which can be explained in part by this fast receptor exchange.
Journal ArticleDOI
Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.
Matthieu F. Bastide,Wassilios G. Meissner,Barbara Picconi,Stefania Fasano,Pierre-Olivier Fernagut,Michael Feyder,Veronica Francardo,Cristina Alcacer,Yunmin Ding,Riccardo Brambilla,Gilberto Fisone,A. Jon Stoessl,Mathieu Bourdenx,Michel Engeln,Sylvia Navailles,Philippe De Deurwaerdère,Wai Kin D. Ko,Nicola Simola,Micaela Morelli,Laurent Groc,Maria Cruz Rodriguez,Eugenia V. Gurevich,Maryka Quik,Michele Morari,Manuela Mellone,Fabrizio Gardoni,Elisabetta Tronci,Dominique Guehl,François Tison,Alan R. Crossman,Un Jung Kang,Kathy Steece-Collier,Susan H. Fox,Manolo Carta,M. Angela Cenci,Erwan Bezard +35 more
TL;DR: The present review attempts to provide an overview of the current understanding of dyskinesia and other L-dopa-induced dysfunctions to help in the development of novel therapeutic strategies aimed at preventing the generation of dyskinetic symptoms.