N
Nadia Naffakh
Researcher at Pasteur Institute
Publications - 107
Citations - 4478
Nadia Naffakh is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Influenza A virus & Virus. The author has an hindex of 34, co-authored 99 publications receiving 4028 citations. Previous affiliations of Nadia Naffakh include Sorbonne & Centre national de la recherche scientifique.
Papers
More filters
Journal ArticleDOI
Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations.
Hélène Quach,Maxime Rotival,Maxime Rotival,Julien Pothlichet,Julien Pothlichet,Yong-Hwee E. Loh,Yong-Hwee E. Loh,Michael Dannemann,Nora Zidane,Nora Zidane,Guillaume Laval,Guillaume Laval,Etienne Patin,Etienne Patin,Christine Harmant,Christine Harmant,Marie Lopez,Matthieu Deschamps,Nadia Naffakh,Darragh Duffy,Anja Coen,Geert Leroux-Roels,Frédéric Clement,Anne Boland,Jean-François Deleuze,Janet Kelso,Matthew L. Albert,Lluis Quintana-Murci,Lluis Quintana-Murci +28 more
TL;DR: The transcriptional response of primary monocytes from Africans and Europeans to bacterial and viral stimuli is characterized and regulatory variants are enriched in population-specific signals of natural selection and admixture with Neandertals introduced regulatory variants into European genomes, affecting preferentially responses to viral challenges.
Journal ArticleDOI
Residue 627 of PB2 Is a Determinant of Cold Sensitivity in RNA Replication of Avian Influenza Viruses
TL;DR: The results suggest that a reduced ability of the polymerase complex of avian viruses to ensure replication of the viral genome at 33°C could contribute to their inability to grow efficiently in humans.
Journal ArticleDOI
Neuraminidase Stalk Length and Additional Glycosylation of the Hemagglutinin Influence the Virulence of Influenza H5N1 Viruses for Mice
Yumiko Matsuoka,David E. Swayne,Colleen Thomas,Marie-Anne Rameix-Welti,Nadia Naffakh,Christine Warnes,Melanie Altholtz,Ruben O. Donis,Kanta Subbarao +8 more
TL;DR: The presence of additional HA glycosylation sites had less of an effect on virulence than did NA stalk length, and the short-stalk NA of H5N1 viruses circulating in Asia may contribute to virulence in humans.
Journal ArticleDOI
Host restriction of avian influenza viruses at the level of the ribonucleoproteins.
TL;DR: Better knowledge of determinants of host restriction will allow monitoring of the pandemic potential of avian influenza viruses, and underlining the influence of the global genetic context.
Journal ArticleDOI
Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts
TL;DR: It is concluded that tetracycline regulation provides a suitable control system for adjusting the delivery of therapeutic proteins from engineered tissues over long periods of time.