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Nadine J.A. Mattheij
Researcher at Maastricht University
Publications - 21
Citations - 1358
Nadine J.A. Mattheij is an academic researcher from Maastricht University. The author has contributed to research in topics: Platelet & Platelet activation. The author has an hindex of 17, co-authored 21 publications receiving 1134 citations.
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Journal ArticleDOI
Platelet-based coagulation: different populations, different functions
TL;DR: It is postulate that different populations of platelets with distinct surface properties are involved in these coagulant functions of blood coagulation.
Journal ArticleDOI
Coordinated membrane ballooning and procoagulant-spreading in human platelets
E.O. Agbani,Marion T.J. van den Bosch,Ed Brown,Christopher Williams,Nadine J.A. Mattheij,Judith M.E.M. Cosemans,Peter William Collins,Johan W. M. Heemskerk,Ingeborg Hers,Alastair W. Poole +9 more
TL;DR: In this article, platelets are transformed into balloon-like structures as part of the hemostatic response by a process that is termed procoagulant spreading, which involves disruption to the platelet microtubule cytoskeleton and inflation through fluid entry.
Journal ArticleDOI
Factor XII Regulates the Pathological Process of Thrombus Formation on Ruptured Plaques
Marijke J.E. Kuijpers,Paola E. J. van der Meijden,Marion A.H. Feijge,Nadine J.A. Mattheij,Frauke May,José W. P. Govers-Riemslag,Joost C. M. Meijers,Johan W. M. Heemskerk,Thomas Renné,Judith M.E.M. Cosemans +9 more
TL;DR: The FVIIa- andFXIIa-triggered coagulation pathways have distinct but complementary roles in atherothrombus formation, whereas FXIIa bound to thrombi ensures thrombus stability.
Journal ArticleDOI
Both TMEM16F-dependent and TMEM16F-independent pathways contribute to phosphatidylserine exposure in platelet apoptosis and platelet activation
Roger van Kruchten,Nadine J.A. Mattheij,Christine Saunders,Marion A.H. Feijge,Frauke Swieringa,Jef L. N. Wolfs,Peter William Collins,Johan W. M. Heemskerk,Edouard M. Bevers +8 more
TL;DR: The role of TMEM16F in apoptosis- or agonist-induced phosphatidylserine (PS) exposure was studied in platelets from a Scott syndrome patient and control subjects, and convulxin-/thrombin-induced PS exposure is entirely dependent on TMEM15F, whereas collagen/thROMbin- induced PS exposure results from 2 distinct pathways, one of which involves mitochondrial depolarization and is mediated by TMEM 16F.
Journal ArticleDOI
Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition.
Florian Beck,Jörg Geiger,Stepan Gambaryan,Fiorella A. Solari,Margherita Dell’Aica,Stefan Loroch,Nadine J.A. Mattheij,Igor Mindukshev,Oliver Pötz,Kerstin Jurk,Julia M. Burkhart,Christian Fufezan,Johan W. M. Heemskerk,Ulrich Walter,René P. Zahedi,Albert Sickmann,Albert Sickmann,Albert Sickmann +17 more
TL;DR: An extensive spectrum of human platelet protein phosphorylation in response to ADP and Iloprost is demonstrated, which inversely overlap and represent major activating and inhibitory pathways.