Nagarajan Kannan

TL;DR: It is shown that the ΔNp63 isoform of the Trp63 transcription factor promotes normal mammary stem cell activity by increasing the expression of the Wnt receptor Fzd7, thereby enhancing Wnt signalling and governs tumour-initiating activity of the basal subtype of breast cancer.

TL;DR: In this article, the authors presented the first formal evidence of the shared and independent ability of basal cells and luminal progenitors, isolated from normal human mammary tissue and transduced with a single oncogene (KRAS(G12D)), to produce serially transplantable, polyclonal, invasive ductal carcinomas within 8 weeks of being introduced either subrenally or subcutaneously into immunodeficient mice.

TL;DR: Trefoil factors (TFFs) are classical estrogen-regulated genes and have served as markers of estrogen gene regulation by various environmental estrogens as discussed by the authors, and are also regulated by several other factors including growth hormone (hGH), insulin-like growth factor-1 (IGF-1), epidermal growth factor (EGF) and various oncogenic stimuli.

TL;DR: A review of the evidence that links progesterone to breast cancer risk and future directions for filling current gaps in knowledge are suggested.

TL;DR: An epigenomic comparison of these three subsets with one another, with their associated stromal cells, and with three immortalized, non-tumorigenic human mammary cell lines shows that each cell type has unique features, primarily within genomic regulatory regions, and that the cell lines group together.