Christina DeCoste

TL;DR: This work uses short hairpin RNA (shRNA) loss-of-function techniques to downregulate a set of gene products whose expression patterns suggest self-renewal regulatory functions, and focuses on transcriptional regulators and identifies seven genes for which shRNA-mediated depletion negatively affects self-Renewal.

TL;DR: It is shown that the ΔNp63 isoform of the Trp63 transcription factor promotes normal mammary stem cell activity by increasing the expression of the Wnt receptor Fzd7, thereby enhancing Wnt signalling and governs tumour-initiating activity of the basal subtype of breast cancer.

TL;DR: Dll1cKO mice have a reduced number of MaSCs at different stages of mammary gland development in virgin and pregnant animals, and it is demonstrated that Dll1+ Ma SCs can both basal and luminal cells generate the important cellular components of the Mammary gland stem cell niche through inter-turning.

TL;DR: It is demonstrated that in addition to regulating terminal differentiation of alveolar cells, Elf5 also plays a critical role in determining cell fate and in regulating the stem/progenitor function of the mammary epithelium.

TL;DR: It is shown that miR-199a promotes stem cell properties in mammary stem cells and breast CSCs by directly repressing nuclear receptor corepressor LCOR, which primes interferon (IFN) responses.