Nancy S. Magnuson

TL;DR: Accumulating data support that the expression of Pim-1 protein is mediated through activation of JAK/STATs, and that this role plays important roles outside of the hematopoietic system as well.

TL;DR: Cardioprotective stimuli associated with Akt activation induced Pim-1 expression, but compensatory increases in Akt abundance and phosphorylation after pathological injury by infarction or pressure overload did not protect the myocardium in Pim–deficient mice, suggesting that PIM-1 is a crucial facet of cardioprotection downstream of Akt.

TL;DR: Overexpression of Pim-1/Pim-2 kinase dramatically stabilizes c-Myc in vivo, and the stabilization is partially mediated by phosphorylation of c-myc by Pim kinase on a novel site, Ser329, which appears to explain at least in part the mechanism underlying the synergism between the Pim Kinases and c- myc in tumorigenesis.

TL;DR: In this article, Pim-1 and Akt are involved in regulation of cellular proliferation and survival but, although Akt is known to be a critical kinase in myocardial signaling, the ro...

TL;DR: It is demonstrated that Pim-1 associates with and phosphorylates p21 in vivo, which influences the subcellular localization of p21.