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Nanette H. Bishopric
Researcher at University of Miami
Publications - 111
Citations - 7752
Nanette H. Bishopric is an academic researcher from University of Miami. The author has contributed to research in topics: Myocyte & Apoptosis. The author has an hindex of 44, co-authored 109 publications receiving 7371 citations. Previous affiliations of Nanette H. Bishopric include United States Department of Veterans Affairs & University of California, San Francisco.
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Journal ArticleDOI
Three-dimensional reconstitution of embryonic cardiomyocytes in a collagen matrix: a new heart muscle model system.
Thomas Eschenhagen,Christine Fink,Ute Remmers,Hasso Scholz,Jens Wattchow,Joachim Weil,Wolfram H. Zimmermann,Hans H. Dohmen,Hansjörg Schäfer,Nanette H. Bishopric,Tetsuro Wakatsuki,Elliot L. Elson +11 more
TL;DR: The utility of this system as a test bed for genetic manipulation was demonstrated by infecting the CMPMs with a recombinant β‐galactosidase‐carrying adenovirus, and transduction efficiency increased from about 5% (MOI 0.1) to about 50% ( MOI 100).
Journal ArticleDOI
Expression of Inducible Nitric Oxide Synthase in Human Heart Failure
Guy A. Haywood,Philip S. Tsao,Heiko E. von der Leyen,Michael J. Mann,Philip J. Keeling,Pedro T. Trindade,Neil P. Lewis,Christopher D. Byrne,Peter Rickenbacher,Nanette H. Bishopric,John P. Cooke,William J. McKenna,Michael B. Fowler +12 more
TL;DR: iNOS expression occurs in failing human cardiac myocytes and may be involved in the pathophysiology of DCM, IHD, and VHD.
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Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3
TL;DR: It is reported that hypoxia-acidosis-associated cell death is mediated by BNIP3, a member of the Bcl-2 family of apoptosis-regulating proteins, and may figure significantly in muscle loss during myocardial ischemia.
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Molecular Regulation of the Endothelin-1 Gene by Hypoxia CONTRIBUTIONS OF HYPOXIA-INDUCIBLE FACTOR-1, ACTIVATOR PROTEIN-1, GATA-2, AND p300/CBP
TL;DR: It is reported that the HIF-1 binding site alone is not sufficient for the response to hypoxia but requires an additional 50 base pairs of flanking sequence that includes binding sites for the factors activator protein-1 (AP-1), GATA-2, and CAAT-binding factor (NF-1).
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Modulation of Cytokine-Induced Cardiac Myocyte Apoptosis by Nitric Oxide, Bak, and Bcl-x
TL;DR: It is concluded that cytokine toxicity to neonatal cardiac myocytes results from the induction of NO and subsequent activation of apoptosis, at least in part through the generation of oxygen free radicals.