N
Nanette S. Roche
Researcher at University of Texas System
Publications - 11
Citations - 5473
Nanette S. Roche is an academic researcher from University of Texas System. The author has contributed to research in topics: Transforming growth factor & Growth factor. The author has an hindex of 9, co-authored 11 publications receiving 5345 citations.
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Journal ArticleDOI
Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.
Anita B. Roberts,Michael B. Sporn,Richard K. Assoian,J M Smith,Nanette S. Roche,Lalage M. Wakefield,U. Heine,Lance A. Liotta,Vincent Falanga,John H. Kehrl +9 more
TL;DR: Further data are obtained to support a role for TGF-beta as an intrinsic mediator of collagen formation: conditioned media obtained from activated human tonsillar T lymphocytes contain greatly elevated levels of T GF-beta compared tomedia obtained from unactivated lymphocytes.
Journal ArticleDOI
Type beta transforming growth factor: a bifunctional regulator of cellular growth.
Anita B. Roberts,Mario A. Anzano,Lalage M. Wakefield,Nanette S. Roche,David F. Stern,Michael B. Sporn +5 more
TL;DR: The data indicate that the effects of TGF-beta on cells are not a function of the peptide itself, but rather of the total set of growth factors and their receptors that is operant in the cell at a given time.
Journal ArticleDOI
A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β
Pellegrino Rossi,Gerard Karsenty,Roberts Ab,Nanette S. Roche,Michael B. Sporn,Benoit de Crombrugghe +5 more
TL;DR: Using DNA transfection, it is shown that TGF-beta stimulates the activity of the mouse alpha 2(l) collagen promoter 5- to 10-fold in mouse NIH 3T3 and rat osteosarcoma cells.
Journal ArticleDOI
Effects of Steroids and Retinoids on Wound Healing
Corinna Wicke,Betty J. Halliday,Daniel B. Allen,Nanette S. Roche,Heinz Scheuenstuhl,Martin M. Spencer,Anita B. Roberts,Thomas K. Hunt +7 more
TL;DR: Steroids and retinoids have antagonistic effects on growth factors and collagen deposition in wound healing and these effects can be relevant for treatment options in a clinical setting.
Journal ArticleDOI
Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice
Klaus Sellheyer,Jackie R. Bickenbach,Joseph A. Rothnagel,Donnie S. Bundman,Mary A. Longley,Thomas Krieg,Nanette S. Roche,Anita B. Roberts,Dennis R. Roop +8 more
TL;DR: The macro- and microscopic appearance of these mice, as well as their neonatal lethality, most likely result from inhibition of normal skin development and suppression of epithelial cell proliferation by the overexpression of transforming growth factor beta 1.