D
Dennis R. Roop
Researcher at Anschutz Medical Campus
Publications - 324
Citations - 26470
Dennis R. Roop is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Keratin & Keratinocyte. The author has an hindex of 78, co-authored 316 publications receiving 25308 citations. Previous affiliations of Dennis R. Roop include University of Tennessee & Baylor College of Medicine.
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Journal ArticleDOI
p63 is a p53 homologue required for limb and epidermal morphogenesis.
TL;DR: P63 is essential for several aspects of ectodermal differentiation during embryogenesis, including hair follicles, teeth and mammary glands, which are absent in p63-deficient mice.
Journal ArticleDOI
Molecular and Cellular Biology of Intermediate Filaments
Peter M. Steinert,Dennis R. Roop +1 more
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Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
Nobunao Wakabayashi,Ken Itoh,Junko Wakabayashi,Hozumi Motohashi,Shuhei Noda,Satoru Takahashi,Sumihisa Imakado,Tomoe Kotsuji,Fujio Otsuka,Dennis R. Roop,Takanori Harada,James Douglas Engel,Masayuki Yamamoto +12 more
TL;DR: These experiments show that Keap1 acts upstream of Nrf2 in the cellular response to oxidative and xenobiotic stress, and breeding to NRF2-deficient mice reversed the phenotypic Keap 1 deficiencies.
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p63 is the molecular switch for initiation of an epithelial stratification program
TL;DR: The data demonstrate that p63 plays a dual role: initiating epithelial stratification during development and maintaining proliferative potential of basal keratinocytes in mature epidermis.
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Multiple defects and perinatal death in mice deficient in follistatin
TL;DR: Follistatin-deficient mice are retarded in then* growth, have decreased mass of the diaphragm and intercostal muscles, shiny taut skin, skeletal defects of the hard palate and the thirteenth pair of ribs, their whisker and tooth development is abnormal, they fail to breathe, and die within hours of birth, indicating that follistatin may modulate the actions of several members of the transforming growth factor-β family.